Interobserver Variability in CT-based Morphologic Tumor Response Assessment of Colorectal Liver Metastases

被引：10

作者：

Wesdorp, Nina J. ^{[1
]}

Kemna, Ruby ^{[1
]}

Bolhuis, Karen ^{[3
]}

van Waesberghe, Jan H. T. M. ^{[2
]}

Nota, Irene M. G. C. ^{[2
]}

Struik, Femke ^{[2
]}

Abdennabi, Ikrame Oulad ^{[2
]}

Phoa, Saffire S. K. S. ^{[2
]}

van Dieren, Susan ^{[4
]}

van Amerongen, Martinus J. ^{[5
]}

Chapelle, Thiery ^{[6
]}

Dejong, Cornelis H. C. ^{[7
,8
]}

Engelbrecht, Marc R. W. ^{[2
]}

Gerhards, Michael F. ^{[9
]}

Grunhagen, Dirk ^{[10
]}

van Gulik, Thomas M. ^{[4
]}

Hermans, John J. ^{[5
]}

de Jong, Koert P. ^{[11
]}

Klaase, Joost M. ^{[11
]}

Liem, Mike S. L. ^{[12
]}

van Lienden, Krijn P. ^{[13
]}

Molenaar, I. Quintus ^{[14
,15
]}

Patijn, Gijs A. ^{[16
]}

Rijken, Arjen M. ^{[17
]}

Ruers, Theo M. ^{[18
]}

Verhoef, Cornelis ^{[10
]}

de Wilt, Johannes H. W. ^{[19
]}

Swijnenburg, Rutger-Jan ^{[4
]}

Punt, Cornelis J. A. ^{[3
,20
]}

Huiskens, Joost ^{[21
]}

Stoker, Jaap ^{[2
]}

Kazemier, Geert ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Surg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Radiol & Nucl Med, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[3] Univ Amsterdam, Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands

[4] Univ Amsterdam, Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Med Imaging, Nijmegen, Netherlands

[6] Antwerp Univ Hosp, Dept Hepatobiliary Transplantat & Endocrine Surg, Antwerp, Belgium

[7] Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands

[8] Univ Kliniknm Aachen, Dept Surg, Aachen, Germany

[9] Onze Lieve Vrouwe Gasthuis Hosp, Dept Surg, Amsterdam, Netherlands

[10] Erasmus MC Canc Inst, Dept Surg Oncol & Gastrointestinal Surg, Rotterdam, Netherlands

[11] Univ Med Ctr Groningen, Dept Hepaosbiliary Surg & Liver Transplantat, Groningen, Netherlands

[12] Med Spectrum Twente, Dept Surg, Enschede, Netherlands

[13] St Antonius Hosp, Dept Intervent Radiol, Nieuwegein, Netherlands

[14] Univ Med Ctr Utrecht, Reg Acad Canc Ctr Utrecht, Dept Surg, Utrecht, Netherlands

[15] St Antonius Hosp, Nieuwegein, Netherlands

[16] Isala Hosp, Dept Surg, Zwolle, Netherlands

[17] Amphia Hosp, Dept Surg, Breda, Netherlands

[18] Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands

[19] Radboud Univ Nijmegen, Radboud Univ Med Ctr, Dept Surg, Nijmegen, Netherlands

[20] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[21] SAS Inst, Dept Hlth, Huizen, Netherlands

来源：

RADIOLOGY-IMAGING CANCER | 2022年 / 4卷 / 03期

关键词：

Tumor Response; Observer Performance; CT; Liver; Metastases; Oncology; Abdomen/Gastrointestinal; PREOPERATIVE CHEMOTHERAPY; CANCER PATIENTS; SURVIVAL; RESECTION; CRITERIA; SURGERY; RADIOMICS; MUTATIONS; OUTCOMES;

D O I：

10.1148/rycan.210105

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To evaluate interobserver variability in the morphologic tumor response assessment of colorectal liver metastases (CRLM) managed with systemic therapy and to assess the relation of morphologic response with gene mutation status, targeted therapy, and Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 measurements. Materials and Methods: Participants with initially unresectable CRLM receiving different systemic therapy regimens from the randomized, controlled CAIRO5 trial (NCT02162563) were included in this prospective imaging study. Three radiologists independently assessed morphologic tumor response on baseline and first follow-up CT scans according to previously published criteria. Two additional radiologists evaluated disagreement cases. Interobserver agreement was calculated by using Fleiss k. On the basis of the majority of individual radiologic assessments, the final morphologic tumor response was determined. Finally, the relation of morphologic tumor response and clinical prognostic parameters was assessed. Results: In total, 153 participants (median age, 63 years [IQR, 56-71]; 101 men) with 306 CT scans comprising 2192 CRLM were included. Morphologic assessment performed by the three radiologists yielded 86 (56%) agreement cases and 67 (44%) disagreement cases (including four major disagreement cases). Overall interobserver agreement between the panel radiologists on morphology groups and morphologic response categories was moderate (k = 0.53, 95% CI: 0.48, 0.58 and k = 0.54, 95% CI: 0.47, 0.60). Optimal morphologic response was particularly observed in patients treated with bevacizumab (P =.001) and in patients with RAS/BRAF mutation (P =.04). No evidence of a relationship between RECIST 1.1 and morphologic response was found (P =.61). Conclusion: Morphologic tumor response assessment following systemic therapy in participants with CRLM demonstrated considerable interobserver variability. (C) RSNA, 2022.

引用

页数：11

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