Utility of certain π-acceptors for the spectrophotometric determination of perindopril

被引:39
作者
Abdellatef, HE [1 ]
机构
[1] Zagazig Univ, Fac Pharm, Dept Analyt Chem, Zagazig, Egypt
关键词
pi-acceptors; spectrophotometric determination; perindopril;
D O I
10.1016/S0731-7085(97)00254-9
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of perindopril. The methods are based on the reaction of this drug as n-electron donor with 2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ)-7,7,8,8-tetracyanoquinodimethane (TCNQ), tetracyanoethylene (TCNE), chloranil (CL) and p-chloranilic acid (p-CA) as pi-acceptors to give highly coloured complex species. The coloured products are measured spectrophotometrically at 588, 843, 419, 550 and 520 nm for DDQ, TCNQ, TCNE, CL and p-CA, respectively optimization of different experimental conditions is described. Beer's law is obeyed in the range of 20-200 mu g ml(-1) and colours were produced in non-aqueous media and were stable for at least 1 h. Application of the suggested methods to perindopril tablets are presented. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1267 / 1271
页数:5
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