Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

被引：62

作者：

Sahoo, Bikash R. ^{[1
,2
]}

Genjo, Takuya ^{[1
,2
]}

Bekier, Michael, II ^{[3
]}

Cox, Sarah J. ^{[1
,2
]}

Stoddard, Andrea K. ^{[1
,2
]}

Ivanova, Magdalena ^{[1
,2
]}

Yasuhara, Kazuma ^{[4
]}

Fierke, Carol A. ^{[1
,2
,5
]}

Wang, Yanzhuang ^{[3
]}

Ramamoorthy, Ayyalusamy ^{[1
,2
]}

机构：

[1] Univ Michigan, Biophys, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Neurol Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[4] Nara Inst Sci & Technol, Grad Sch Mat Sci, Ikoma, Nara 6300192, Japan

[5] Texas A&M Univ, College Stn, TX 77843 USA

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 91期

关键词：

PARTIALLY FOLDED STRUCTURE; A-BETA; BINDING; MODELS; SHAPE;

D O I：

10.1039/c8cc07921h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (approximate to 10 nm) and macro-nanodiscs (>15 nm) are used to study A(1-40) aggregation. We demonstrate that PMA-nanodiscs form a ternary association with A and regulate its aggregation kinetics by trapping intermediates. Results demonstrating the reduced neurotoxicity of nanodisc-bound A oligomers are also reported.

引用

页码：12883 / 12886

页数：4

共 24 条

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