Synthesis and anticonvulsant activity of halo-substituted aryl urea and thioureas

被引：0

作者：

Gupta, Mahesh Kumar ^{[1
]}

Pandeya, Suerendra N. ^{[2
]}

Zaiad, Golal M. ^{[3
]}

Gangwar, V. S. ^{[4
]}

机构：

[1] Prabhat Engn Coll, Kanpur Dehat 209304, Uttar Pradesh, India

[2] Saroj Inst Technol & Management, Lucknow 226004, Uttar Pradesh, India

[3] Al Margeb Univ, Dept Chem, Al Khums, Libya

[4] VSSD Coll, Kanpur 208002, Uttar Pradesh, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2010年 / 87卷 / 11期

关键词：

Aryl urea; thiourea; synthesis; phenytoin;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Halo-substituted arylureas have been prepared by condensation of halo-substituted primary arylamine with sodium cyanate and halo-substituted arylthioureas have been prepared by condensation of halo-substituted primary arylamine with ammonium thiocyanate in presence of acid The structures of compounds synthesized base been confirmed by elemental analysis and spectral data Their anticonvulsant activity was evaluated, p-bromophenyl urea and p: chlorophenyl and p-bromophenyl thioureas were found to be most active in the maximal electro shock (MFS) test p-Bromophenyl derivatives were found least neurotoxic in the rotorod test The results were compared with standard drug phenytoin

引用

页码：1421 / 1424

页数：4

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