Quantitative Susceptibility Mapping: Basic Methods and Clinical Applications

被引：53

作者：

Harada, Taisuke ^{[1
,2
,4
]}

Kudo, Kohsuke ^{[1
,3
,4
]}

Fujima, Noriyuki ^{[4
]}

Yoshikawa, Masato ^{[1
,4
]}

Ikebe, Yohei ^{[4
]}

Sato, Ryota ^{[5
]}

Shirai, Toru ^{[5
]}

Bito, Yoshitaka ^{[6
]}

Uwano, Ikuko ^{[7
]}

Miyata, Mari ^{[8
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Diagnost Imaging, Kita Ku, N15 W7, Sapporo, Hokkaido, Japan

[2] Hokkaido Univ, Fac Med, Ctr Cause Death Invest, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Fac Med, Global Ctr Biomed Sci & Engn, Sapporo, Hokkaido, Japan

[4] Hokkaido Univ Hosp, Dept Diagnost & Intervent Radiol, Sapporo, Hokkaido, Japan

[5] Fujifilm Healthcare Corp, Innovat Technol Lab, Tokyo, Japan

[6] Fujifilm Healthcare Corp, Chiba, Japan

[7] Iwate Med Univ, Inst Biomed Sci, Div Ultrahigh Field MRI, Yahaba, Iwate, Japan

[8] Natl Inst Quantum Sci & Technol, Quantum Life & Med Sci Directorate, Inst Quantum Med Sci, Dept Funct Brain Imaging, Chiba, Japan

来源：

RADIOGRAPHICS | 2022年 / 42卷 / 04期

关键词：

MULTIPLE-SCLEROSIS; MAGNETIC-SUSCEPTIBILITY; DENTATE NUCLEUS; BASAL GANGLIA; EARLY-STAGE; IRON; DIAGNOSIS; DISEASE; BRAIN; GRAY;

D O I：

10.1148/rg.210054

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Quantitative susceptibility mapping (QSM), one of the advanced MRI techniques for evaluating magnetic susceptibility, offers precise quantitative measurements of spatial distributions of magnetic susceptibility. Magnetic susceptibility describes the magnetizability of a material to an applied magnetic field and is a substance-specific value. Recently, QSM has been widely used to estimate various levels of substances in the brain, including iron, hemosiderin, and deoxyhemoglobin (paramagnetism), as well as calcification (diamagnetism). By visualizing iron distribution in the brain, it is possible to identify anatomic structures that are not evident on conventional images and to evaluate various neurodegenerative diseases. It has been challenging to apply QSM in areas outside the brain because of motion artifacts from respiration and heartbeats, as well as the presence of fat, which has a different frequency to the proton. In this review, the authors provide a brief overview of the theoretical background and analyze methods of converting MRI phase images to QSM. Moreover, we provide an overview of the current clinical applications of QSM. (C) RSNA, 2022

引用

页码：1161 / 1176

页数：16

共 67 条

[1] Comparison of T2*-weighted and QSM contrasts in Parkinson's disease to visualize the STN with MRI [J].