Endocrine-Disrupting Chemicals and Disorders of Penile Development in Humans

被引：10

作者：

Gaspari, Laura ^{[1
,2
,3
]}

Tessier, Benoit ^{[5
]}

Paris, Francoise ^{[1
,2
,3
]}

Bergougnoux, Anne ^{[1
,4
]}

Hamamah, Samir ^{[3
,6
]}

Sultan, Charles ^{[1
]}

Kalfa, Nicolas ^{[1
,5
,7
]}

机构：

[1] Univ Montpellier, CHU Montpellier, Hop Lapeyronie, Ctr Reference Malad Rares Dev Genit DEVGEN,Consti, Montpellier, France

[2] Univ Montpellier, CHU Montpellier, Hop Arnaud de Villeneuve, Unite Endocrinol Gynecol Pediat,Serv Pediat, Montpellier, France

[3] Univ Montpellier, Dev Embryonnaire Fertilite Environm, INSERM 1203, Montpellier, France

[4] Univ Montpellier, CNRS UMR, Lab Genet Mol, PhyMedExp, Montpellier, France

[5] Univ Montpellier, Dept Chirurg Viscerale & Urolog Pediat, Hop Lapeyronie, CHU Montpellier, Montpellier, France

[6] Univ Montpellier, Dept Biol Reprod, Biol Reprod DPI & CECOS, CHU Montpellier, Montpellier, France

[7] Univ Montpellier, Inst Debrest Sante Publ IDESP, UMR INSERM, Montpellier, France

来源：

SEXUAL DEVELOPMENT | 2021年 / 15卷 / 1-3期

关键词：

Organic chemicals; Penis; Pollution; Disorders of sex development; Endocrine disruptors; Environment; Hypospadias; Micropenis; POLYBROMINATED DIPHENYL ETHERS; POLYCYCLIC AROMATIC-HYDROCARBONS; TESTICULAR DYSGENESIS SYNDROME; RISK-FACTOR PATTERNS; PRENATAL EXPOSURE; BISPHENOL-A; BIRTH-DEFECTS; MALE NEWBORNS; CONGENITAL-ANOMALIES; REPRODUCTIVE DISORDERS;

D O I：

10.1159/000517157

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This paper reviews the current knowledge on the environmental effects on penile development in humans. The specific focus is on endocrine-disrupting chemicals (EDCs), a heterogeneous group of natural or manmade substances that interfere with endocrine function, and whether they can induce hypospadias and micropenis in male neonates. Epidemiological data and animal observations first raised suspicions about environmental effects, leading to the testis dysgenesis syndrome (TDS) hypothesis. More recent research has provided stronger indications that TDS may indeed be the result of the direct or indirect effects of EDCs. Drawing on epidemiological and toxicological studies, we also report on the effects of maternal diet and substances like pesticides, phthalates, bisphenol A, and polychlorinated biphenyls. Proximity to contamination hazards and occupational exposure are also suspected to contribute to the occurrence of hypospadias and micropenis. Lastly, the cumulative effects of EDCs and the possibility of transgenerational effects, with the penile development of subsequent generations being affected, raise concerns for long-term public health.

引用

页码：213 / 228

页数：16

共 197 条

[1] Prenatal exposures to bisphenol A and di (2-ethylhexyl) phthalate disrupted seminiferous tubular development in growing male rats [J].