The bovine serum albumine influence on the character of the autholytic alterations of the lipid component of rat brain grey and white matters tissue in vitro

The influence of cytoprotecting concentrations of bovine serum albumin (BSA) on the autholytic alterations of rat brain white and grey matters in the physiological solution containing was investigated. In the autholysed grey matter exogenous BSA prevents the decomposition of phospholipids and the gaining the free fatty acids up to 1 hr of incubation and increased the content of cholesterol esters at the 4th and 24th hrs of autholysis. BSA increased the phospholypids breakdown at the late stages of autholysis (24 ks). On the contrary, BSA activated the phospholypids break down in the white matter already at the early periods of incubation (10 mins). It aeso altered the character of cholesterol and esters pendulous interactions on the opposite one, promoting the significant increase of the latters, especially at the 10th min and 4th hr of the autholysis.