Impact of maternal pre-pregnancy overweight on infant overweight at 1year of age: associations and sex-specific differences

Background Maternal overweight or obesity (OWOB) is linked to gestational diabetes, fetal macrosomia and higher rates of caesarean delivery. ObjectivesMethodsThe study aims to assess whether maternal pre-pregnancy OWOB is associated with infant overweight in a sex-dependent manner, independent of microbiota-altering variables. Weight and length measurements of 955 mother-infant pairs were obtained from the Canadian Healthy Infant Longitudinal Development cohort. Maternal pre-pregnancy weight was defined as follows: normal, overweight (25body mass index<30) and obese (body mass index30). Age and sex-adjusted weight-for-length z-scores >97th percentile were classified as infant overweight at age 1year. Associations between pre-pregnancy and infant overweight were determined by linear and logistic regression, adjusting for covariates. ResultsConclusionsMaternal pre-pregnancy OWOB were associated with infant weight-for-length and overweight risk at 1year. Except for pre-pregnancy obesity, these associations were not attenuated appreciably after adjustment for birth mode, exclusivity of breastfeeding, exposure to antibiotics and infant sex. Yet only boys born to mothers with obesity were three times more likely to become overweight at age 1 independent of microbiota-altering variables. Pre-pregnancy obesity was associated with weight-for-length in male and female infants. Maternal pre-pregnancy OWOB increases the risk of infant overweight, and this association is more evident in male infants.