Helicobacter heilmannii sensu lato: An overview of the infection in humans

被引：38
作者：
Bento-Miranda, Mario [1 ]
Figueiredo, Ceu [1 ,2 ]
机构：
[1] Univ Porto, Fac Med, Dept Pathol & Oncol, P-4200465 Oporto, Portugal
[2] Univ Porto, Inst Mol Pathol & Immunol, P-4200465 Oporto, Portugal
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 47期
关键词：
Helicobacter heilmannii sensu lato; Gastric non-Helicobacter pylori; Helicobacter species; Pathogenesis; Diagnosis; Treatment; Genomes; CHRONIC ACTIVE GASTRITIS; TISSUE MALT LYMPHOMA; LONG-TERM INFECTION; GASTROSPIRILLUM-HOMINIS; SUIS INFECTION; MOUSE MODEL; PYLORI-HELICOBACTER; SPIRAL ORGANISMS; GENOME SEQUENCE; ANIMAL-MODEL;
D O I：
10.3748/wjg.v20.i47.17779
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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页码：17779 / 17787
页数：9
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