Statins, inflammation, and sepsis - Hypothesis

被引：87

作者：

Almog, Y ^{[1
]}

机构：

[1] Soroka Univ, Med Ctr, Med Intens Care Unit, Fac Hlth Sci,Ben Gurion Univ, IL-84101 Beer Sheva, Israel

来源：

CHEST | 2003年 / 124卷 / 02期

关键词：

anti-inflammatory; apoptosis; nitric oxide; sepsis; statins;

D O I：

10.1378/chest.124.2.740

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many Immoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

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页码：740 / 743

页数：4

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