Anti-N-methyl-d-aspartate receptor encephalitis: A case series and review of the literature

被引：5

作者：

John, Cheri M. ^{[1
]}

Mathew, Deepa E. ^{[2
]}

Abdelaziz, Maysara ^{[3
]}

Mahmoud, Add A. H. ^{[4
]}

AlOtaihi, Ali D. ^{[5
]}

Sohal, Aman P. S. ^{[6
]}

机构：

[1] Angels Special Clin, AL-190,1st St,12th Main Rd, Chennai 600040, Tamil Nadu, India

[2] Apollo Special Hosp, Chennai, Tamil Nadu, India

[3] St Helens & Knowsley NHS Trust, Prescot, England

[4] Natl Neurosci Inst, Riyadh, Saudi Arabia

[5] King Fahad Med City, Riyadh, Saudi Arabia

[6] Neuropedia Childrens Neurosci Ctr, Dubai, U Arab Emirates

来源：

JOURNAL OF PEDIATRIC NEUROSCIENCES | 2019年 / 14卷 / 04期

关键词：

Encephalitis; N-methyl-d-aspartate; N-methyl-d-aspartate receptor; AUTOIMMUNE ENCEPHALITIS; ANTIBODIES; DIAGNOSIS; CHILDREN;

D O I：

10.4103/jpn.JPN_83_19

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Anti-NMDAR (N-methyl-d-aspartate receptor) encephalitis is a potentially severe form of encephalitis associated with antibodies against NR1 and NR2 subunits of the NMDAR. Anti-NMDAR encephalitis is a treatable cause of encephalitis. An underlying tumor should be actively looked for as this is also considered to be a paraneoplastic syndrome. We report two children with anti-NMDAR encephalitis with a literature review of current evidence in diagnosing and managing this rare condition. Resection of the tumor, glucocorticoids, intravenous immunoglobulin, and plasma exchange often result in improvement, usually within four weeks. Outcome corresponds with the rapidity of commencing appropriate treatment.

引用

页码：180 / 185

页数：6

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