SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking

被引：68

作者：

Alexander, T. ^{[1
]}

Bondanza, A. ^{[2
]}

Muraro, P. A. ^{[3
]}

Greco, R. ^{[2
]}

Saccardi, R. ^{[4
]}

Daikeler, T. ^{[5
]}

Kazmi, M. ^{[6
]}

Hawkey, C. ^{[7
]}

Simoes, P. ^{[8
]}

Leblanc, K. ^{[9
]}

Fibbe, W. E. ^{[10
]}

Moore, J. ^{[11
]}

Snarski, E. ^{[12
]}

Martin, T. ^{[13
]}

Hiepe, F. ^{[1
]}

Velardi, A. ^{[14
]}

Toubert, A. ^{[15
]}

Snowden, J. A. ^{[16
,17
]}

Farge, D. ^{[18
]}

机构：

[1] Charite, Dept Rheumatol & Clin Immunol, D-10117 Berlin, Germany

[2] Ist Sci San Raffaele, Hematol & Bone Marrow Transplantat Unit, I-20132 Milan, Italy

[3] Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Brain Sci, London, England

[4] Careggi Univ Hosp, Dept Haematol, Cord Blood Bank, Florence, Italy

[5] Univ Basel Hosp, Dept Rheumatol, CH-4031 Basel, Switzerland

[6] Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England

[7] Nottingham Digest Dis Ctr, Nottingham, England

[8] Univ Sao Paulo, Sch Med, Dept Clin Med, BR-14049 Ribeirao Preto, Brazil

[9] Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden

[10] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Leiden, Netherlands

[11] St Vincents Hosp, Dept Haematol, Sydney, NSW 2010, Australia

[12] Med Univ Warsaw, Dept Hematol Oncol & Internal Dis, Warsaw, Poland

[13] Strasbourg Univ Hosp, Strasbourg, France

[14] Univ Perugia, Dept Med, Div Haematol, I-06100 Perugia, Italy

[15] Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis, AP HP,Immunol Lab,Inserm U1160, Paris, France

[16] Sheffield Teaching Hosp NHS Fdn Trust, Dept Haematol, Sheffield, S Yorkshire, England

[17] Univ Sheffield, Sheffield, S Yorkshire, England

[18] Univ Paris 07, Hop St Louis, AP HP, Unite Med Interne & Pathol Vasc,INSERM U1160, Paris, France

来源：

BONE MARROW TRANSPLANTATION | 2015年 / 50卷 / 02期

关键词：

STEM-CELL TRANSPLANTATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; MULTIPLE-SCLEROSIS; RHEUMATOID-ARTHRITIS; CROHNS-DISEASE; NEUROMYELITIS-OPTICA; RECONSTITUTION; PATHOGENESIS;

D O I：

10.1038/bmt.2014.251

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Over the past 15 years, SCT has emerged as a promising treatment option for patients with severe autoimmune diseases (ADs). Mechanistic studies recently provided the proof-of-concept that restoration of immunological tolerance can be achieved by haematopoietic SCT in chronic autoimmunity through eradication of the pathologic, immunologic memory and profound reconfiguration of the immune system, that is, immune 'resetting'. Nevertheless, a number of areas remain unresolved and warrant further investigation to refine our understanding of the underlying mechanisms of action and to optimize clinical SCT protocols. Due to the low number of patients transplanted in each centre, it is essential to adequately collect and analyse biological samples in a larger cohort of patients under standardized conditions. The European society for blood and marrow transplantation Autoimmune Diseases and Immunobiology Working Parties have, therefore, undertaken a joint initiative to develop and implement guidelines for 'good laboratory practice' in relation to procurement, processing, storage and analysis of biological specimens for immune reconstitution studies in AD patients before, during and after SCT. The aim of this document is to provide practical recommendations for biobanking of samples and laboratory immune monitoring in patients with ADs undergoing SCT, both for routine supportive care purposes and investigational studies.

引用

页码：173 / 180

页数：8

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