The Preclinical Research Progress of Stem Cells Therapy in Parkinson's Disease

被引：2

作者：

Zhang, Jun ^{[1
]}

Wang, Xianyun ^{[1
]}

Li, Jing ^{[1
,2
]}

Huang, Rui ^{[3
]}

Yu, Xuerui ^{[4
]}

Dong, Ci ^{[5
]}

Liu, Pujuan ^{[6
]}

Zhang, Fan ^{[1
]}

Hu, Jie ^{[7
]}

Qi, Yixin ^{[8
]}

Zhang, Jing ^{[3
]}

Li, Quanhai ^{[1
,2
]}

Yan, Baoyong ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 1, Cell Therapy Lab, Shijiazhuang 050031, Hebei, Peoples R China

[2] Hebei Med Univ, Basic Med Coll, Dept Immunol, Shijiazhuang 050017, Hebei, Peoples R China

[3] Hebei Med Univ, Hosp 1, Dept Paediat, Shijiazhuang 050031, Hebei, Peoples R China

[4] Hebei Med Univ, Hosp 1, Dept Gen Surg, Shijiazhuang 050031, Hebei, Peoples R China

[5] Hebei Med Univ, Hosp 1, Dept Neurol, Shijiazhuang 050031, Hebei, Peoples R China

[6] Hebei Med Univ, Hosp 1, Dept Cardiac Surg, Shijiazhuang 050031, Hebei, Peoples R China

[7] Hebei Med Univ, Sch Nursing, Shijiazhuang, Hebei, Peoples R China

[8] Hebei Med Univ, Hosp 4, Dept Breast Ctr, Shijiazhuang, Hebei, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷

关键词：

MARROW STROMAL CELLS; NEURONS IN-VITRO; DOPAMINERGIC-NEURONS; ANIMAL-MODELS; RAT MODEL; TRANSPLANTATION; DIFFERENTIATION; NEUROGENESIS; GENERATION; DISORDERS;

D O I：

10.1155/2016/5683097

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Parkinson's disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed.

引用

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