Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients

被引：23

作者：

Pluta, Agnieszka ^{[1
]}

Wrzesien-Kus, Agata ^{[1
]}

Cebula-Obrzut, Barbara ^{[2
]}

Wolska, Anna ^{[1
]}

Szmigielska-Kaplon, Anna ^{[1
]}

Czemerska, Magdalena ^{[1
]}

Pluta, Piotr ^{[3
]}

Robak, Tadeusz ^{[1
]}

Smolewski, Piotr ^{[2
]}

Wierzbowska, Agnieszka ^{[1
]}

机构：

[1] Med Univ Lodz, Copernicus Mem Hosp, Dept Hematol, PL-93510 Lodz, Poland

[2] Med Univ Lodz, Copernicus Mem Hosp, Dept Expt Hematol, PL-93510 Lodz, Poland

[3] Med Univ Lodz, Copernicus Mem Hosp, Dept Surg Oncol, PL-93510 Lodz, Poland

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 10期

关键词：

Acute myeloid leukemia; Smac/DIABLO; Apoptosis; Prognosis; X-LINKED INHIBITOR; SERINE-PROTEASE; APOPTOSIS; IDENTIFICATION; ANTAGONISTS; CARCINOMAS; ACTIVATION; OMI/HTRA2; BINDING; SMAC;

D O I：

10.1016/j.leukres.2009.11.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of the Smac/DIABLO protein, a novel apoptosis agonist, in acute myeloid leukemia (AML) is not clearly determined. The expression of Smac/DIABLO protein in AML leukemic cells and its relationship with clinical outcome was evaluated in this study. The intracellular expression of Smac/DIABLO protein was assessed using multi-color flow cytometry in 71 newly diagnosed AML patients treated with conventional chemotherapy. It was found that the high expression of Smac/DIABLO protein was an independent prognostic factor in terms of higher complete remission rate (p < 0.001) and longer overall survival (p = 0.003). Moreover the low expression of Smac/DIABLO protein was associated with poor karyotype. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1308 / 1313

页数：6

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