Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients

被引：23
|
作者：
Pluta, Agnieszka [1 ]
Wrzesien-Kus, Agata [1 ]
Cebula-Obrzut, Barbara [2 ]
Wolska, Anna [1 ]
Szmigielska-Kaplon, Anna [1 ]
Czemerska, Magdalena [1 ]
Pluta, Piotr [3 ]
Robak, Tadeusz [1 ]
Smolewski, Piotr [2 ]
Wierzbowska, Agnieszka [1 ]
机构：
[1] Med Univ Lodz, Copernicus Mem Hosp, Dept Hematol, PL-93510 Lodz, Poland
[2] Med Univ Lodz, Copernicus Mem Hosp, Dept Expt Hematol, PL-93510 Lodz, Poland
[3] Med Univ Lodz, Copernicus Mem Hosp, Dept Surg Oncol, PL-93510 Lodz, Poland
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 10期
关键词：
Acute myeloid leukemia; Smac/DIABLO; Apoptosis; Prognosis; X-LINKED INHIBITOR; SERINE-PROTEASE; APOPTOSIS; IDENTIFICATION; ANTAGONISTS; CARCINOMAS; ACTIVATION; OMI/HTRA2; BINDING; SMAC;
D O I：
10.1016/j.leukres.2009.11.030
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of the Smac/DIABLO protein, a novel apoptosis agonist, in acute myeloid leukemia (AML) is not clearly determined. The expression of Smac/DIABLO protein in AML leukemic cells and its relationship with clinical outcome was evaluated in this study. The intracellular expression of Smac/DIABLO protein was assessed using multi-color flow cytometry in 71 newly diagnosed AML patients treated with conventional chemotherapy. It was found that the high expression of Smac/DIABLO protein was an independent prognostic factor in terms of higher complete remission rate (p < 0.001) and longer overall survival (p = 0.003). Moreover the low expression of Smac/DIABLO protein was associated with poor karyotype. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1308 / 1313
页数：6
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