Spectrum of Newcastle disease virus stability in gradients of temperature and pH

被引:11
作者
Rani, Surabhi [1 ]
Gogoi, Polakshee [1 ]
Kumar, Sachin [1 ]
机构
[1] Indian Inst Technol Guwahati, Dept Biotechnol, Gauhati 781039, Assam, India
关键词
Vaccine failure; Temperature; Virus stability; Virus titration; AVIAN INFLUENZA-VIRUS; PARAMYXOVIRUS FUSION; INACTIVATION; THERMOSTABILITY; STRAINS; VACCINE; PROTEIN; NDV;
D O I
10.1016/j.biologicals.2014.08.006
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Newcastle disease (ND) is one of the highly pathogenic viral diseases of avian species. The disease is endemic in many developing countries where agriculture serves as the primary source of national income. Newcastle disease virus (NDV) belongs to the family Paramyxoviridae and is well characterized member among the avian paramyxovirus serotypes. The failure of vaccination is one of the major causes of NDV outbreaks in field condition. The present study gives a brief picture about the biology of NDV genome and its proteins under different conditions of temperature and pH. Our results indicate that the NDV is non-infective above 42 degrees C and unstable above 72 degrees C. The study will be useful in defining an optimum storage condition for NDV without causing any deterioration in its viability. (C) 2014 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:351 / 354
页数:4
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