Correlation of Immune Cells and Cytokines in the Tumor Microenvironment with Elevated Neutrophil-To-Lymphocyte Ratio in Blood: An Analysis of Muscle-Invasive Bladder Cancer

被引：21

作者：

Morizawa, Yosuke ^{[1
]}

Miyake, Makito ^{[1
]}

Shimada, Keiji ^{[2
,3
]}

Hori, Shunta ^{[1
]}

Tatsumi, Yoshihiro ^{[1
,3
]}

Nakai, Yasushi ^{[1
]}

Onishi, Sayuri ^{[1
]}

Tanaka, Nobumichi ^{[1
]}

Konishi, Noboru ^{[3
]}

Fujimoto, Kiyohide ^{[1
]}

机构：

[1] Nara Med Univ, Dept Urol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan

[2] Nara City Hosp, Dept Pathol, Nara, Japan

[3] Nara Med Univ, Dept Pathol, Kashihara, Nara, Japan

来源：

CANCER INVESTIGATION | 2018年 / 36卷 / 07期

基金：

日本学术振兴会;

关键词：

NLR; Foxp3; IL-6; IL-8; muscle-invasive bladder cancer; UROTHELIAL CARCINOMA; RADICAL CYSTECTOMY; PROGNOSTIC-SIGNIFICANCE; FOXP3; EXPRESSION; INFLAMMATION; PREDICTOR; RECURRENCE; SURVIVAL; OUTCOMES; STAGE;

D O I：

10.1080/07357907.2018.1506800

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the relationship between Neutrophil-to-lymphocyte ratio (NLR) and the quantities of neutrophil elastase, CD3, Foxp3, and CD204 in tumor-infiltrating cells and circulating cytokines (IL-2, -6, -8, 17a, and TGF-beta) in muscle-invasive bladder cancer. IL-6 and IL-8 levels showed a significant correlation with NLR in blood and Foxp3+ cells around the tumor. After co-culture of peripheral blood cells with bladder cancer cell lines, the induction of regulatory T cell (Treg) was higher in T24 whose IL-6 and IL-8 levels were higher. High NLR correlates with increased IL-6 and IL-8 and Treg expression.

引用

页码：395 / 405

页数：11

共 50 条

[31] Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Nonmuscle-Invasive Bladder Cancer Treated with GreenLight Laser Vaporization [J].

Luo, Fei ;

Ma, Chunlei ;

Wu, Jianhui ;

Li, Jian .

PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY, 2019, 37 (05) :312-317

[32] Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer [J].

Liu, Chien-Liang ;

Lee, Jie-Jen ;

Liu, Tsang-Pai ;

Chang, Yuan-Ching ;

Hsu, Yi-Chiung ;

Cheng, Shih-Ping .

JOURNAL OF SURGICAL ONCOLOGY, 2013, 107 (05) :493-497

[33] Neutrophil-to-lymphocyte ratio predicts a poor prognosis for penile cancer with an immunosuppressive tumor microenvironment [J].

Tan, Xingliang ;

Wang, Yanjun ;

Yu, Yiqi ;

Zheng, Runhao ;

Li, Jing ;

Chen, Shaohua ;

Xie, Qingling ;

Guo, Shengjie ;

Zhang, Chichen ;

Deng, Xinpei ;

Liu, Zhicheng ;

Tang, Yi ;

Li, Hang ;

Wu, Weicheng ;

Chen, Juexiao ;

Zhou, Qianghua ;

Wei, Wensu ;

Yao, Kai ;

Wu, Zhiming .

FRONTIERS IN IMMUNOLOGY, 2025, 16

[34] Prognostic value of neutrophil-to-lymphocyte ratio in patients with non-muscle-invasive bladder cancer with intravesical Bacillus Calmette-Guérin immunotherapy: a systematic review and meta-analysis [J].

Huang, Jiaguo ;

Lin, Li ;

Mao, Dikai ;

Hua, Runmiao ;

Guan, Feifei .

FRONTIERS IN IMMUNOLOGY, 2024, 15

[35] Tumor immune microenvironment dynamics and outcomes of prognosis in non-muscle-invasive bladder cancer [J].

Kamitani, Rei ;

Tanaka, Nobuyuki ;

Anno, Tadatsugu ;

Murakami, Tetsushi ;

Masuda, Tsukasa ;

Yasumizu, Yota ;

Takeda, Toshikazu ;

Morita, Shinya ;

Kosaka, Takeo ;

Mikami, Shuji ;

Matsumoto, Kazuhiro ;

Oya, Mototsugu .

CANCER SCIENCE, 2024, 115 (12) :3963-3972

[36] Prognostic Analysis of Neutrophil/Lymphocyte Ratio and Thrombocyte/Lymphocyte Value Before Trimodal Treatment in Invasive Bladder Cancer [J].

Inanc, Berrin ;

Mermut, Ozlem .

ISTANBUL MEDICAL JOURNAL, 2020, 21 (02) :82-87

[37] Preoperative neutrophil-lymphocyte ratio can significantly predict mortality outcomes in patients with non-muscle invasive bladder cancer undergoing transurethral resection of bladder tumor [J].

Kang, Minyong ;

Jeong, Chang Wook ;

Kwak, Cheol ;

Kim, Hyeon Hoe ;

Ku, Ja Hyeon .

ONCOTARGET, 2017, 8 (08) :12891-12901

[38] Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Non-Muscle Invasive Bladder Cancer treated with Intravesical Bacillus Calmette-Guerin and the Relationship with the CUETO Scoring Model [J].

Chung, Jae-Wook ;

Kim, Jin Woo ;

Lee, Eun Hye ;

Chun, So Young ;

Park, Dong Jin ;

Byeon, Kyeong Hyeon ;

Choi, Seock Hwan ;

Lee, Jun Nyung ;

Kim, Bum Soo ;

Kim, Hyun Tae ;

Yoo, Eun Sang ;

Kwon, Tae Gyun ;

Ha, Yun-Sok ;

Kim, Tae-Hwan .

UROLOGY JOURNAL, 2022, 19 (04) :281-288

[39] A Novel Immune-Gene Pair Signature Revealing the Tumor Microenvironment Features and Immunotherapy Prognosis of Muscle-Invasive Bladder Cancer [J].

Zheng, Xiaonan ;

Zhou, Xianghong ;

Xu, Hang ;

Jin, Di ;

Yang, Lu ;

Shen, Bairong ;

Qiu, Shi ;

Ai, Jianzhong ;

Wei, Qiang .

FRONTIERS IN GENETICS, 2021, 12

[40] A classification based on tumor-stroma ratio and tumor budding for patients with muscle-invasive bladder cancer [J].

Liu, Junqiang ;

Li, Chun ;

Huang, Kai ;

Aldanakh, Abdullah ;

Yang, Deyong ;

Wang, Jianbo ;

Sun, Xiuzhen ;

Song, Xishuang .

EXPERT REVIEW OF ANTICANCER THERAPY, 2022, 22 (03) :323-330

← 1 2 3 4 5 →