Correlation of Immune Cells and Cytokines in the Tumor Microenvironment with Elevated Neutrophil-To-Lymphocyte Ratio in Blood: An Analysis of Muscle-Invasive Bladder Cancer

被引：22
|
作者：
Morizawa, Yosuke [1 ]
Miyake, Makito [1 ]
Shimada, Keiji [2 ,3 ]
Hori, Shunta [1 ]
Tatsumi, Yoshihiro [1 ,3 ]
Nakai, Yasushi [1 ]
Onishi, Sayuri [1 ]
Tanaka, Nobumichi [1 ]
Konishi, Noboru [3 ]
Fujimoto, Kiyohide [1 ]
机构：
[1] Nara Med Univ, Dept Urol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan
[2] Nara City Hosp, Dept Pathol, Nara, Japan
[3] Nara Med Univ, Dept Pathol, Kashihara, Nara, Japan
来源：
CANCER INVESTIGATION | 2018年 / 36卷 / 07期
基金：
日本学术振兴会;
关键词：
NLR; Foxp3; IL-6; IL-8; muscle-invasive bladder cancer; UROTHELIAL CARCINOMA; RADICAL CYSTECTOMY; PROGNOSTIC-SIGNIFICANCE; FOXP3; EXPRESSION; INFLAMMATION; PREDICTOR; RECURRENCE; SURVIVAL; OUTCOMES; STAGE;
D O I：
10.1080/07357907.2018.1506800
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the relationship between Neutrophil-to-lymphocyte ratio (NLR) and the quantities of neutrophil elastase, CD3, Foxp3, and CD204 in tumor-infiltrating cells and circulating cytokines (IL-2, -6, -8, 17a, and TGF-beta) in muscle-invasive bladder cancer. IL-6 and IL-8 levels showed a significant correlation with NLR in blood and Foxp3+ cells around the tumor. After co-culture of peripheral blood cells with bladder cancer cell lines, the induction of regulatory T cell (Treg) was higher in T24 whose IL-6 and IL-8 levels were higher. High NLR correlates with increased IL-6 and IL-8 and Treg expression.
引用
收藏
页码：395 / 405
页数：11
相关论文
共 50 条
  • [1] Neutrophil-to-lymphocyte ratio as a detection marker of tumor recurrence in patients with muscle-invasive bladder cancer after radical cystectomy
    Morizawa, Yosuke
    Miyake, Makito
    Shimada, Keiji
    Hori, Shunta
    Tatsumi, Yoshihiro
    Nakai, Yasushi
    Anai, Satoshi
    Tanaka, Nobumichi
    Konishi, Noboru
    Fujimoto, Kiyohide
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2016, 34 (06) : 257.e11 - 257.e17
  • [2] The Significance of Neutrophil-to-Lymphocyte Ratio and Combined Chemoradiotherapy in Patients Undergoing Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer
    Wu, Chun-Te
    Huang, Yun-Ching
    Chen, Wen-Cheng
    Chen, Miao-Fen
    CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 13125 - 13135
  • [3] Neutrophil-Lymphocyte Ratio and Pathological Response to Neoadjuvant Chemotherapy in Patients With Muscle-Invasive Bladder Cancer
    Seah, Jo-An
    Leibowitz-Amit, Raya
    Atenafu, Eshetu G.
    Alimohamed, Nimira
    Knox, Jennifer J.
    Joshua, Anthony M.
    Sridhar, Srikala S.
    CLINICAL GENITOURINARY CANCER, 2015, 13 (04) : E229 - E233
  • [4] The Prognostic Role of the Change in Neutrophil-to-Lymphocyte Ratio During Neoadjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer: A Retrospective, Multi-Institutional Study
    Kaiser, Jeenan
    Li, Haocheng
    North, Scott A.
    Leibowitz-Amit, Raya
    Seah, Jo-An
    Morshed, Nisha
    Chau, Caroline
    Lee-Ying, Richard
    Heng, Daniel Y. C.
    Sridhar, Srikala
    Crabb, Simon J.
    Alimohamed, Nimira S.
    BLADDER CANCER, 2018, 4 (02) : 185 - 194
  • [5] The prognostic value of the neutrophil-to-lymphocyte ratio in patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy
    Black, Anna J.
    Zargar, Homayoun
    Zargar-Shoshtari, Kamran
    Fairey, Adrian S.
    Mertens, Laura S.
    Dinney, Colin P.
    Mir, Maria C.
    Krabbe, Laura-Maria
    Cookson, Michael S.
    Jacobsen, Niels-Erik
    Griffin, Joshua
    Montgomery, Jeffrey S.
    Vasdev, Nikhil
    Yu, Evan Y.
    Xylinas, Evanguelos
    Campain, Nicholas J.
    Kassouf, Wassim
    Dall'Era, Marc A.
    Seah, Jo-An
    Ercole, Cesar E.
    Horenblas, Simon
    McGrath, John S.
    Aning, Jonathan
    Shariat, Shahrokh F.
    Wright, Jonathan L.
    Thorpe, Andrew C.
    Morgan, Todd M.
    Holzbeierlein, Jeff M.
    Bivalacqua, Trinity J.
    North, Scott
    Barocas, Daniel A.
    Lotan, Yair
    Grivas, Petros
    Stephenson, Andrew J.
    Shah, Jay B.
    van Rhijn, Bas W.
    Spiess, Philippe E.
    Daneshmand, Siamak
    Sridhar, Srikala S.
    Black, Peter C.
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2020, 38 (01) : 3.e17 - 3.e27
  • [6] Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Primary Non-muscle-invasive Bladder Cancer
    D'Andrea, David
    Moschini, Marco
    Gust, Kilian
    Abufaraj, Mohammad
    Ozsoy, Mehmet
    Mathieu, Romain
    Soria, Francesco
    Briganti, Alberto
    Roupret, Morgan
    Karakiewicz, Pierre I.
    Shariat, Shahrokh F.
    CLINICAL GENITOURINARY CANCER, 2017, 15 (05) : E755 - E764
  • [7] Neutrophil-to-lymphocyte ratio predicts progression and recurrence of non-muscle-invasive bladder cancer
    Mano, Roy
    Baniel, Jack
    Shoshany, Ohad
    Marge, David
    Bar-On, Tomer
    Nativ, Ofer
    Rubinstein, Jacob
    Halachmi, Sarel
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2015, 33 (02) : 67.e1 - 67.e7
  • [8] Neutrophil-to-lymphocyte ratio is elevated in recurring nonmuscle invasive bladder cancer
    Yuruk, Emrah
    Saitz, Theodore Robert
    Gonultas, Serkan
    Serefoglu, Ege Can
    Muslumanoglu, Ahmet Yaser
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2017, 47 (01) : 234 - 239
  • [9] PROGNOSTIC VALUES OF PREOPERATIVE NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELET-TO-LYMPHOCYTE RATIO AND LYMPHOCYTE-TO-MONOCYTE RATIO FOR PATIENTS WITH MUSCLE-INVASIVE BLADDER CANCER UNDERGOING RADICAL CYSTECTOMY
    Lei, Yonghua
    Jiao, Dian
    Yao, Zhen
    Wang, Lei
    Zhao, Zhiguang
    ARCHIVOS ESPANOLES DE UROLOGIA, 2022, 75 (03): : 287 - 294
  • [10] Preoperative neutrophil-lymphocyte ratio and fibrinogen level in patients distinguish between muscle-invasive bladder cancer and non-muscle-invasive bladder cancer
    Ma, Chengquan
    Lu, Bingxin
    Diao, Chengwen
    Zhao, Kun
    Wang, Xinpeng
    Ma, Baojing
    Lu, Baojian
    Sun, Erlin
    ONCOTARGETS AND THERAPY, 2016, 9 : 4917 - 4922
12345