Molecular and neural mediators of leptin action

被引：131
作者：
Robertson, Scott A.
Leinninger, Gina M.
Myers, Martin G., Jr.
机构：
[1] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48109 USA
来源：
PHYSIOLOGY & BEHAVIOR | 2008年 / 94卷 / 05期
关键词：
leptin receptor; STAT3; hypothalamus; Jak2; feeding;
D O I：
10.1016/j.physbeh.2008.04.005
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
The adipose tissue-derived hormone, leptin, acts via its receptor (LepRb) in the brain to regulate energy balance and neuroendocrine function. Parsing the biology of leptin requires understanding LepRb signaling and the roles for specific signaling pathways in neural and physiological leptin action. Since the leptin acts via a broadly distributed network of LepRb-expressing neurons, understanding the function of each of these LepRb neural populations will also be crucial. Here, we review the status of knowledge regarding the molecular mediators of leptin action and the neural substrate via which leptin acts to regulate physiologic processes. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：637 / 642
页数：6
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