Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base-Free Conditions

被引：170

作者：

Dai, Chao ^{[1
,2
]}

Xu, Zhaoqing ^{[1
]}

Huang, Fei ^{[1
]}

Yu, Zhengkun ^{[1
]}

Gao, Yan-Feng ^{[2
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Zhengzhou Univ, Dept Bioengn, Zhengzhou 450001, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 09期

关键词：

PHASE TRANSFER CATALYSIS; DIRECT ARYLATION; BIOLOGICAL-ACTIVITIES; S-ALKYLATION; FUNCTIONALIZATIONS; HETEROCYCLES; BENZOXAZOLE; DISULFIDES; INHIBITORS; COMPLEXES;

D O I：

10.1021/jo202624s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Lewis acid (Ag-I, Ni-II, or Fe-II) catalyzed, Cu-II-mediated thiolation reaction between heteroarenes and thiols was achieved with good yield under base-free conditions. DMSO could serve as an effective methylthiolation reagent for the synthesis of heterocyclic methyl thioethers.

引用

页码：4414 / 4419

页数：6

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