Synthesis and evaluation of antioxidant and antimicrobial properties of thymol containing pyridone moieties

被引：22

作者：

Nagle, P. S. ^{[1
]}

Pawar, Y. A. ^{[1
]}

Sonawane, A. E. ^{[1
]}

Bhosale, S. M. ^{[1
]}

More, D. H. ^{[1
]}

机构：

[1] N Maharashtra Univ, Sch Chem Sci, Jalgaon 425001, Maharashtra, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 07期

关键词：

Thymol; Pyridone; Antioxidant activity; Antifungal activity; Antibacterial activity; DERIVATIVES;

D O I：

10.1007/s00044-011-9656-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Various derivatives of 1,2-dihydro-6-(4-hydroxy-5-isopropyl-2-methylphenyl)-2-oxo-4-arylpyridine-3-carbonitrile (IVa-m) were synthesized and characterized. Their antioxidant and antimicrobial properties were evaluated by measuring their activity in vitro. Among the newly synthesized derivatives IVg, IVh, IVi, IVj, IVk, IVl, and IVm showed good antioxidant activity. However, all derivatives show better antibacterial and antifungal properties than that of parent thymol. The probable mechanism, particularly for antioxidant properties of these compounds is proposed.

引用

页码：1395 / 1402

页数：8

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