Vascular cell adhesion molecule-1 as a biochemical marker of left ventricular mass in the patients with hypertension

被引：32
作者：
Kuroda, YT
Komamura, K
Tatsumi, R
Mori, K
Yoneda, K
Katayama, Y
Shigemoto, S
Miyatake, K
Hanafusa, T
机构：
[1] Natl Cardiovasc Ctr, Res Inst, Dept Cardiovasc Dynam, Suita, Osaka 5658565, Japan
[2] Osaka Second Police Hosp, Ibaraki, Osaka, Japan
[3] Osaka Med Coll, Takatsuki, Osaka 569, Japan
来源：
AMERICAN JOURNAL OF HYPERTENSION | 2001年 / 14卷 / 09期
关键词：
hypertension; hypertrophy; cell adhesion molecules;
D O I：
10.1016/S0895-7061(01)02139-2
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and E-selectin were measured in 80 outpatients with uncomplicated essential hypertension. Although the levels of E-selectin and sICAM-1 were similar between the patients with and without left ventricular (LV) hypertrophy, sVCAM-1 level was significantly elevated in the patients with LV hypertrophy (759.7 +/- 154.6 ng/mL nu 984.4 +/- 240.6 ng/mL, P < .0001). The LV mass normalized to body surface area or height were significantly correlated with sVCAM-1 (r = 0.615, P < .0001 and r = 0.571, P < .0001, respectively). These results indicate that a soluble adhesion molecule is correlated with LV mass in uncomplicated essential hypertensive patients. (C) 2001 American Journal of Hypertension, Ltd.
引用
收藏
页码：868 / 872
页数：5
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