Melanoma in adolescents and young adults (ages 15-39 years): United States, 1999-2006

被引:112
作者
Weir, Hannah K. [1 ]
Marrett, Loraine D. [3 ]
Cokkinides, Vilma [5 ]
Barnholtz-Sloan, Jill [4 ]
Patel, Pragna [2 ]
Tai, Eric [1 ]
Jemal, Ahmedin [5 ]
Li, Jun [1 ]
Kim, Julian [6 ]
Ekwueme, Donatus U. [1 ]
机构
[1] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA
[2] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Hepatitis Sexually Transmitted Dis &, Atlanta, GA 30341 USA
[3] Canc Care Ontario, Populat Studies & Surveillance, Toronto, ON, Canada
[4] Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH USA
[5] Amer Canc Soc, Atlanta, GA 30329 USA
[6] Univ Hosp Cleveland, Dept Surg, Case Med Ctr, Div Surg Oncol, Cleveland, OH 44106 USA
关键词
adolescents; cancer; incidence; melanoma; National Program of Cancer Registries; surveillance; Surveillance Epidemiology and End Results; young adults; CUTANEOUS MALIGNANT-MELANOMA; RECENT TRENDS; SUN EXPOSURE; CANCER; RISK; US; WOMEN; SUNSCREEN; RATES; SKIN;
D O I
10.1016/j.jaad.2011.04.038
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Invasive melanoma of the skin is the third most common cancer diagnosed among adolescents and young adults (aged 15-39 years) in the United States. Understanding the burden of melanoma in this age group is important to identifying areas for etiologic research and in developing effective prevention approaches aimed at reducing melanoma risk. Methods: Melanoma incidence data reported from 38 National Program of Cancer Registries and/or Surveillance Epidemiology and End Results statewide cancer registries covering nearly 67.2% of the US population were used to estimate age-adjusted incidence rates for persons 15-39 years of age. Incidence rate ratios were calculated to compare rates between demographic groups. Results: Melanoma incidence was higher among females (age-adjusted incidence rates = 9.74; 95% confidence interval 9.62-9.86) compared with males (age-adjusted incidence rates = 5.77; 95% confidence interval 5.68-5.86), increased with age, and was higher in non-Hispanic white compared with Hispanic white and black, American Indians/Alaskan Natives, and Asian and Pacific Islanders populations. Melanoma incidence rates increased with year of diagnosis in females but not males. The majority of melanomas were diagnosed on the trunk in all racial and ethnic groups among males but only in non-Hispanic whites among females. Most melanomas were diagnosed at localized stage, and among those melanomas with known histology, the majority were superficial spreading. Limitations: Accuracy of melanoma cases reporting was limited because of some incompleteness (delayed reporting) or nonspecific reporting including large proportion of unspecified histology. Conclusions: Differences in incidence rates by anatomic site, histology, and stage among adolescents and young adults by race, ethnicity, and sex suggest that both host characteristics and behaviors influence risk. These data suggest areas for etiologic research around gene-environment interactions and the need for targeted cancer control activities specific to adolescents and young adult populations. (J Am Acad Dermatol 2011;65:S38-49.)
引用
收藏
页码:S38 / S49
页数:12
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