Modes of Brain Cell Death Following Intracerebral Hemorrhage

被引：56

作者：

Zhang, Yan ^{[1
,2
]}

Khan, Suliman ^{[1
,2
]}

Liu, Yang ^{[1
,2
]}

Zhang, Ruiyi ^{[1
,2
]}

Li, Hongmin ^{[1
,2
]}

Wu, Guofeng ^{[3
]}

Tang, Zhouping ^{[4
]}

Xue, Mengzhou ^{[1
,2
]}

Yong, V. Wee ^{[5
,6
]}

机构：

[1] Zhengzhou Univ, Dept Cerebrovasc Dis, Affiliated Hosp 2, Zhengzhou, Peoples R China

[2] Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R China

[3] Guizhou Med Univ, Dept Emergency, Affiliated Hosp, Guiyang, Peoples R China

[4] Huazhong Univ Sci & Technol, Affiliated Tongji Hosp, Dept Neurol, Tongji Med Coll, Wuhan, Peoples R China

[5] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[6] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2022年 / 16卷

基金：

中国国家自然科学基金;

关键词：

intracerebral hemorrhage; cell death; apoptosis; necrosis; ferroptosis; autophagy; parthanatos; SUBARACHNOID HEMORRHAGE; NEUROLOGICAL FUNCTION; NEURONAL NECROPTOSIS; HYDROGEN INHALATION; CEREBRAL VASOSPASM; POTENTIAL ROLE; CYTOCHROME-C; INJURY; APOPTOSIS; FERROPTOSIS;

D O I：

10.3389/fncel.2022.799753

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.

引用

页数：15

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