Melanin diagnostics with nonlinear optics: a mini-review

被引：1

作者：

Shirshin, E. A. ^{[1
,2
]}

Yakimov, B. P. ^{[1
,2
,3
]}

Budylin, G. S. ^{[3
,4
]}

Buyankin, K. E.

Armaganov, A. G. ^{[2
]}

Fadeev, V. V. ^{[1
]}

Kamalov, A. A. ^{[2
]}

机构：

[1] Lomonosov Moscow State Univ, Fac Phys, Leninskie Gory 1,Stroenie 2, Moscow 119991, Russia

[2] Lomonosov Moscow State Univ, Med Res & Educ Ctr, Lomonosovskii Posp 27,Korp 10, Moscow 119192, Russia

[3] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Minist Hlth Russian Federat, World Class Res Ctr Digital Biodesign & Personali, Ul Trubetskaya 8,Stroenie 2, Moscow 119991, Russia

[4] Russian Acad Sci, Inst Spect, Ul Fizicheskaya 5, Moscow 108840, Russia

来源：

QUANTUM ELECTRONICS | 2022年 / 52卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

multiphoton microscopy; visualisation of fluorescence decay time; FLIM; CARS; melanin; nonlinear processes; multiquantum processes; pump; probe spectroscopy; 3RD HARMONIC-GENERATION; IN-VIVO; RAMAN-SPECTROSCOPY; FLUORESCENCE; MICROSCOPY; IDENTIFICATION; TOMOGRAPHY; LESIONS; CELLS; STATE;

D O I：

10.1070/QEL17963

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Optical methods are widely used to perform fundamental studies of living systems and solve problems of biomedical diagnostics. Along with the classical spectroscopy, methods of nonlinear optics (e.g., multiphoton microscopy) are also applied in biophotonics. The potential of nonlinear optical methods for visualisation and analysis of the properties of endogenous chromophore molecules are considered in this minireview. Melanin - a pigment with specific spectral features of photophysical properties in the visible and nearIR ranges - is taken as an example. It is discussed what information about its localisation in tissues and structural organisation can be obtained by nonlinear optical methods: multiphoton fluorescence microscopy (including fluorescence lifetime imaging), third harmonic generation, pump - probe spectroscopy, and coherent anti Stokes Raman spectroscopy.

引用

页码：28 / 35

页数：9

共 65 条

[21] Vibrational characterization of pheomelanin and trichochrome F by Raman spectroscopy [J].