A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

被引：104

作者：

Zhao, Wenru ^{[1
]}

Zhang, Hongti ^{[1
]}

He, Qianjun ^{[2
]}

Li, Yongsheng ^{[1
]}

Gu, Jinlou ^{[1
]}

Li, Liang ^{[1
]}

Li, Hua ^{[1
]}

Shi, Jianlin ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Adv Funct Mat Lab, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 33期

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

DRUG-DELIVERY; HEMOGLOBIN;

D O I：

10.1039/c1cc12740c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.

引用

页码：9459 / 9461

页数：3

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