Paraminabeolides A-F, Cytotoxic and Anti-inflammatory Marine Withanolides from the Soft Coral Paraminabea acronocephala

被引：46

作者：

Chao, Chih-Hua ^{[1
]}

Chou, Kuei-Ju ^{[1
]}

Wen, Zhi-Hong ^{[1
,2
]}

Wang, Guey-Horng ^{[3
]}

Wu, Yang-Chang ^{[4
]}

Dai, Chang-Feng ^{[5
]}

Sheu, Jyh-Horng ^{[1
,2
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[3] Chia Nan Univ Pharm & Sci, Dept Cosmet Sci, Tainan 717, Taiwan

[4] China Med Univ, Coll Chinese Med, Taichung 404, Taiwan

[5] Natl Taiwan Univ, Inst Oceanog, Taipei 106, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 05期

关键词：

IMMUNOSUPPRESSIVE ACTIVITY; PHYSALIS-PHILADELPHICA; QUINONE REDUCTASE; CONSTITUENTS; INDUCTION; DUN;

D O I：

10.1021/np2000705

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new withanolides, paraminabeolides A-F (1-6), along with five known compounds, minabeolides-1, -2, -4, -5, and -8 (7-11), were isolated from a Formosan soft coral, Paraminabea acronocephata. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The absolute configuration of 4 was determined by the application of Mosher's method. Compounds 1 and 7 were cytotoxic toward Hep G2 cancer cells. Compounds 1-4 and 7-10 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein. Compounds 7-10 also could effectively reduce the expression of COX-2 protein.

引用

页码：1132 / 1141

页数：10

共 27 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] ANTI-INFLAMMATORY ACTIVITY OF 3-BETA-HYDROXY-2,3-DIHYDRO-WITHANOLIDE-F [J].

BUDHIRAJA, RD ;

SUDHIR, S ;

GARG, KN .

PLANTA MEDICA, 1984, 50 (02) :134-136

[3] ANTI-MICROBIAL ACTIVITIES OF SOME ANTI-NEOPLASTIC AND OTHER WITHANOLIDES [J].

CHATTERJEE, S ;

CHAKRABORTI, SK .

ANTONIE VAN LEEUWENHOEK JOURNAL OF MICROBIOLOGY, 1980, 46 (01) :59-63

[4]

Dutta SK, 1985, INDIAN J CANC CHEMOT, V7, P59

[5] Total synthesis and evaluation of the actin-binding properties of microcarpalide and a focused library of analogues [J].

Fuerstner, Alois ;

Nagano, Takashi ;

Mueller, Christoph ;

Seidel, Guenter ;

Mueller, Oliver .

CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (05) :1452-1462

[6]

Gu JQ, 2003, CHEM PHARM BULL, V51, P530, DOI 10.1248/cpb.51.530

[7] PLANT ANTICANCER AGENTS .20. CONSTITUENTS OF NICANDRA-PHYSALODES [J].

GUNASEKERA, SP ;

CORDELL, GA ;

FARNSWORTH, NR .

PLANTA MEDICA, 1981, 43 (04) :389-391

[8] Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium [J].

Habtemariam, S .

PLANTA MEDICA, 1997, 63 (01) :15-17

[9] Cytotoxic withanolides from Tubocapsicum anomalum [J].

Hsieh, Pei-Wen ;

Huang, Zih-You ;

Chen, Jyun-Hong ;

Chang, Fang-Rong ;

Wu, Ching-Chung ;

Yang, Yu-Liang ;

Chiang, Michael Y. ;

Yen, Ming-Hon ;

Chen, Shu-Li ;

Yen, Hsin-Fu ;

Lubken, Tilo ;

Hung, Wen-Chun ;

Wu, Yang-Chang .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (05) :747-753

[10] COTTON EFFECTS AND CONFORMATIONS OF SKELETALLY ISOMERIC SATURATED 3-OXO-STEROIDS [J].

JACOBS, HJC ;

HAVINGA, E .

TETRAHEDRON, 1972, 28 (01) :135-&

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