Pathophysiology and treatment of neuropathic pain associated with syringomyelia

被引：71
作者：
Rusbridge, Clare [1 ]
Jeffery, Nick D. [2 ]
机构：
[1] Stone Lion Vet Ctr, London SW19 5AU, England
[2] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England
来源：
VETERINARY JOURNAL | 2008年 / 175卷 / 02期
关键词：
neuropathic pain; allodynia; dysaesthesia; spinal cord dorsal horn; Cavalier King Charles Spaniel;
D O I：
10.1016/j.tvjl.2006.12.007
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The pain behaviour expressed by dogs with syringomyelia suggests that they experience neuropathic pain, probably due to disordered neural processing in the damaged dorsal horn. As such it is likely that conventional analgesic medication will be ineffective. In this review, physiological and pathological pain processing through the dorsal horn is summarised and mechanisms by which syringomyelia could result in a persistent pain state are discussed. Finally, current knowledge regarding treatment of Chiari malformation and syringomyelia, is reviewed and possible drugs which may give improved pain relief in affected dogs are discussed. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：164 / 172
页数：9
相关论文
共 93 条
  • [11] 2
  • [12] CENTRAL DYSESTHESIA SYNDROME IN SPINAL-CORD INJURY PATIENTS
    BERIC, A
    DIMITRIJEVIC, MR
    LINDBLOM, U
    [J]. PAIN, 1988, 34 (02) : 109 - 116
  • [13] Brearley J, 2000, PAIN MANAGEMENT ANIM, P147, DOI [10.1016/B978-0-7020-1767-4.50009-6, DOI 10.1016/B978-0-7020-1767-4.50009-6]
  • [14] Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain
    Broom, DC
    Samad, TA
    Kohno, T
    Tegeder, I
    Geisslinger, G
    Woolf, CJ
    [J]. NEUROSCIENCE, 2004, 124 (04) : 891 - 900
  • [15] Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat
    Christensen, MD
    Hulsebosch, CE
    [J]. EXPERIMENTAL NEUROLOGY, 1997, 147 (02) : 463 - 475
  • [16] Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate
    Coderre, TJ
    Kumar, N
    Lefebvre, CD
    Yu, JSC
    [J]. JOURNAL OF NEUROCHEMISTRY, 2005, 94 (04) : 1131 - 1139
  • [17] Ketamine patient-controlled analgesia for dysesthetic central pain
    Cohen, SP
    DeJesus, M
    [J]. SPINAL CORD, 2004, 42 (07) : 425 - 428
  • [18] Large-amplitude 5-HT1A receptor activation:: a new mechanism of profound, central analgesia
    Colpaert, FC
    Tarayre, JP
    Koek, W
    Pauwels, PJ
    Bardin, L
    Xu, XJ
    Wiesenfeld-Hallin, Z
    Cosi, C
    Carilla-Durand, E
    Assié, MB
    Vacher, B
    [J]. NEUROPHARMACOLOGY, 2002, 43 (06) : 945 - 958
  • [19] High-efficacy 5-HT1A receptor activation causes a curative-like action on allodynia in rats with spinal cord injury
    Colpaert, FC
    Wu, WP
    Hao, JX
    Royer, I
    Sautel, F
    Wiesenfeld-Hallin, Z
    Xu, XJ
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 497 (01) : 29 - 33
  • [20] Pain: Molecular mechanisms
    Costigan, M
    Woolf, CJ
    [J]. JOURNAL OF PAIN, 2000, 1 (03) : 35 - 44
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