Nanosized drug formulations under microfluidic continuous flow

被引：32

作者：

Dev, Selvi ^{[1
]}

Iyer, K. Swaminathan ^{[1
]}

Raston, Colin L. ^{[1
]}

机构：

[1] Univ Western Australia, Ctr Strateg Nanofabricat, Sch Biomed Biomol & Chem Sci, Crawley, WA 6009, Australia

来源：

LAB ON A CHIP | 2011年 / 11卷 / 19期

关键词：

MICELLAR NANOCONTAINERS; POSTOPERATIVE PAIN; MELOXICAM; DELIVERY; SYSTEM; OPTIMIZATION; GENE;

D O I：

10.1039/c1lc20666d

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a simple method involving a rotating tube processor to fabricate ultrafine crystalline drug nanoparticles under microfluidic continuous flow with precise control over particle size, with significantly enhanced dissolution of the drug.

引用

页码：3214 / 3217

页数：4

共 29 条

[11]

Hong Y, 2006, PHARMAZIE, V61, P312

[12] Enhancing drug function [J].

Hubbell, JA .

SCIENCE, 2003, 300 (5619) :595-596

[13] Effects of penetration enhancers on in vitro permeability of meloxicam gels [J].

Jantharaprapap, R. ;

Stagni, G. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 343 (1-2) :26-33

[14] Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery [J].

Kabanov, AV ;

Batrakova, EV ;

Alakhov, VY .

JOURNAL OF CONTROLLED RELEASE, 2002, 82 (2-3) :189-212

[15] Pluronic® block copolymers in drug delivery:: From micellar nanocontainers to biological response modifiers [J].

Kabanov, AV ;

Alakhov, VY .

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2002, 19 (01) :1-72

[16] Block copolymer micelles for delivery of gene and related compounds [J].

Kakizawa, Y ;

Kataoka, K .

ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (02) :203-222

[17]

Langer R, 2001, SCIENCE, V293, P58, DOI 10.1126/science.1063273

[18] Inverse targeting of reticuloendothelial system-rich organs after intravenous administration of adriamycin-loaded neutral proliposomes containing poloxamer 407 to rats [J].

Lee, HJ ;

Ahn, BN ;

Paik, WH ;

Shim, CK ;

Lee, MG .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 131 (01) :91-96

[19] Structure and physicochemical properties of meloxicam, a new NSAID [J].

Luger, P ;

Daneck, K ;

Engel, W ;

Trummlitz, G ;

Wagner, K .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 4 (03) :175-187

[20] PEGylated nanoparticles for biological and pharmaceutical applications [J].

Otsuka, H ;

Nagasaki, Y ;

Kataoka, K .

ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (03) :403-419

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