Polysaccharide from Echinacea purpurea reduce the oxidant stress in vitro and in vivo

被引：38

作者：

Hou, Ranran ^{[1
]}

Xu, Tianli ^{[1
]}

Li, Qiu ^{[1
]}

Yang, Fengfang ^{[1
]}

Wang, Chunyuan ^{[1
]}

Huang, Tingting ^{[1
]}

Hao, Zhihui ^{[1
,2
]}

机构：

[1] Qingdao Agr Univ, Agr Biopharmaceut Lab, Qingdao, Peoples R China

[2] China Agr Univ, Coll Vet Med, Beijing, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 149卷

基金：

中国国家自然科学基金;

关键词：

Echinacea purpurea polysaccharide; Antioxidant activity; Free radical scavenging test; Oxidative damage model; NF-KAPPA-B; INDUCED OXIDATIVE STRESS; ANTIOXIDANT ACTIVITIES; APOPTOSIS; ACTIVATION; SULFORAPHANE; INHIBITION; PROTEINS; EXTRACTS; PROTECTS;

D O I：

10.1016/j.ijbiomac.2020.01.129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Echinacea purpurea polysaccharides (EPPS) were extracted through water extract and alcohol precipitate method. Three polysaccharides were purified by DEAE cellulose, named EPPS-1, EPPS-2 and EPPS-3. The antioxidant activities in three polysaccharides were screened by free radical scavenging test and EPPS-3 possessed the best antioxidant function. Then the antioxidant activities of EPPS-3 were further explored in oxidative damage model in vitro and in vivo for the first time.The results showed that the antioxidases and the metabolism content were significantly improved in EPPS-3 group. EPPS-3 could protect hepatic tissue from the injury of CCL4 compared with the oxidative damage model. The mechanism research demonstrated that EPPS-3 restrained cell apoptosis and promoted Nrf2 cell signal pathway to play an antioxidant impact. Therefore, EPPS-3 an ingredient could be served as amazing gift for food industry and feed additive. (C) 2020 Published by Elsevier B.V.

引用

页码：41 / 50

页数：10

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