Bioinspired tunable hydrogels: An update on methods of preparation, classification, and biomedical and therapeutic applications

Hydrogels exhibit water-insoluble three-dimensional polymeric networks capable of absorbing large amounts of biological fluids. Both natural and synthetic polymers are used for the preparation of hydrogel networks. Such polymeric networks are fabricated through chemical or physical mechanisms of crosslinking. Chemical crosslinking is accomplished mainly through covalent bonding, while physical crosslinking involves self-healing secondary forces like H-bonding, host-guest interactions, and antigen-antibody interactions. The building blocks of the hydrogels play an important role in determining the mechanical, biological, and physicochemical properties. Hydrogels are used in a variety of biomedical applications like diagnostics (biodetection and bioimaging), delivery of therapeutics (drugs, immunotherapeutics, and vaccines), wound dressing and skin materials, cardiac complications, contact lenses, tissue engineering, and cell culture because of the inherent characteristics like enhanced water uptake and structural similarity with the extracellular matrix (ECM). This review highlights the recent trends and advances in the roles of hydrogels in biomedical and therapeutic applications. We also discuss the classification and methods of hydrogels preparation. A brief outlook on the future directions of hydrogels is also presented.