Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease

被引：65
作者：
Yadlapati, Rena [1 ]
Delay, Kelli [1 ]
机构：
[1] Univ Colorado, Div Gastroenterol & Hepatol, Anschutz Med Campus,12631 East 17th Ave B158, Aurora, CO 80045 USA
来源：
MEDICAL CLINICS OF NORTH AMERICA | 2019年 / 103卷 / 01期
关键词：
PPI-refractory; Antireflux surgery; Fundoplication; Magnetic sphincter augmentation; Gastroesophageal reflux disease (GERD); COMPETITIVE ACID BLOCKER; ANTIREFLUX SURGERY; RADIOFREQUENCY ENERGY; FUNDOPLICATION TIF; STRETTA PROCEDURE; SYMPTOMS; VONOPRAZAN; MANAGEMENT; THERAPY; GERD;
D O I：
10.1016/j.mcna.2018.08.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) is defined by the presence of troublesome GERD symptoms despite PPI optimization for at least 8 weeks in the setting of ongoing documented pathologic gastroesophageal reflux. It arises from a dysfunction in protective systems to prevent reflux and as propagation of physiologic reflux events. Treatment possibilities include pharmacologic options, invasive management strategies, and endoluminal therapies. Management strategy should be personalized to the patient's needs and mechanistic dysfunction. This article reviews the definition, mechanisms, and management options for PPI-refractory GERD.
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收藏
页码：15 / +
页数：14
相关论文
共 75 条
[1]  
Abbasinazari M, 2014, IRAN J PHARM RES, V13, P1221
[2]   PRIMARY PERISTALSIS IS THE MAJOR ACID CLEARANCE MECHANISM IN REFLUX PATIENTS [J].
ANGGIANSAH, A ;
TAYLOR, G ;
BRIGHT, N ;
WANG, J ;
OWEN, WA ;
ROKKAS, T ;
JONES, AR ;
OWEN, WJ .
GUT, 1994, 35 (11) :1536-1542
[3]   Influence of radiofrequency energy delivery at the gastroesophageal junction (the stretta procedure) on symptoms, acid exposure, and esophageal sensitivity to acid perfusion in gastroesophagal reflux disease [J].
Arts, J. ;
Sifrim, D. ;
Rutgeerts, P. ;
Lerut, A. ;
Janssens, J. ;
Tack, J. .
DIGESTIVE DISEASES AND SCIENCES, 2007, 52 (09) :2170-2177
[4]   A Double-Blind Sham-Controlled Study of the Effect of Radiofrequency Energy on Symptoms and Distensibility of the Gastro-Esophageal Junction in GERD [J].
Arts, J. ;
Bisschops, R. ;
Blondeau, K. ;
Farre, R. ;
Vos, R. ;
Holvoet, L. ;
Caenepeel, P. ;
Lerut, A. ;
Tack, Jan .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 (02) :222-230
[5]   Randomised clinical trial: vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis [J].
Ashida, K. ;
Sakurai, Y. ;
Hori, T. ;
Kudou, K. ;
Nishimura, A. ;
Hiramatsu, N. ;
Umegaki, E. ;
Iwakiri, K. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2016, 43 (02) :240-251
[6]   Mucosal Impedance Discriminates GERD From Non-GERD Conditions [J].
Ates, Fehmi ;
Yuksel, Elif Saritas ;
Higginbotham, Tina ;
Slaughter, James C. ;
Mabary, Jerry ;
Kavitt, Robert T. ;
Garrett, C. Gaelyn ;
Francis, David ;
Vaezi, Michael F. .
GASTROENTEROLOGY, 2015, 148 (02) :334-343
[7]   Surgical Anti-Reflux Options Beyond Fundoplication [J].
Azagury D. ;
Morton J. .
Current Gastroenterology Reports, 2017, 19 (7)
[8]   Magnetic Augmentation of the Lower Esophageal Sphincter: Results of a Feasibility Clinical Trial [J].
Bonavina, Luigi ;
Saino, Greta I. ;
Bona, Davide ;
Lipham, John ;
Ganz, Robert A. ;
Dunn, Daniel ;
DeMeester, Tom .
JOURNAL OF GASTROINTESTINAL SURGERY, 2008, 12 (12) :2133-2140
[9]   Relationship between gastro-oesophageal reflux pattern and severity of mucosal damage [J].
Bredenoord, A. J. ;
Hemmink, G. J. M. ;
Smout, A. J. P. M. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2009, 21 (08) :807-812
[10]   Favorable results from a prospective evaluation of 200 patients with large hiatal hernias undergoing LINX magnetic sphincter augmentation [J].
Buckley, F. P., III ;
Bell, Reginald C. W. ;
Freeman, Kate ;
Doggett, Stephanie ;
Heidrick, Rachel .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2018, 32 (04) :1762-1768
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