Mutation, sequence analysis, and association studies of α-synuclein in Parkinson's disease

被引：68

作者：

Parsian, A

Racette, B

Zhang, ZH

Chakraverty, S

Rundle, M

Goate, A

Perlmutter, JS

机构：

[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA

来源：

NEUROLOGY | 1998年 / 51卷 / 06期

关键词：

D O I：

10.1212/WNL.51.6.1757

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the alpha-synuclein gene. None of the familial cases of PD carried a mutation within the alpha-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the alpha-synuclein gene. We conclude that variation within the alpha-synuclein gene does not play a significant role in the risk for PD in our sample.

引用

页码：1757 / 1759

页数：3

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