The first ferrocene analogues of muramyldipeptide

被引：15

作者：

Barisic, Lidija ^{[1
]}

Roscic, Maja ^{[2
]}

Kovacevic, Monika ^{[1
]}

Semencic, Mojca Cakic ^{[1
]}

Horvat, Stefica ^{[2
]}

Rapic, Vladimir ^{[1
]}

机构：

[1] Fac Food Technol & Biotechnol, Dept Organ Chem, HR-10000 Zagreb, Croatia

[2] Rudjer Boskovic Inst, Div Organ Chem & Biochem, HR-10000 Zagreb, Croatia

来源：

CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 05期

关键词：

Ferrocene; 1 '-Aminoferrocene-1-carboxylic acid (Fca); Muramyldipeptide (MDP); beta-Turn; Intramolecular hydrogen bond (IHB); ALANYL-D-ISOGLUTAMINE; D-IGLN MDP; MURAMYL DIPEPTIDE; 1'-AMINOFERROCENE-1-CARBOXYLIC ACID; NONSPECIFIC IMMUNITY; CYTOTOXIC ACTIVITY; SUPEROXIDE ANION; PEPTIDES; BENZYL; NMR;

D O I：

10.1016/j.carres.2011.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two structurally interesting bioorganometallic analogues of muramyldipeptide (MDP) with potential immunomodulatory activity were synthesized starting from the O-protected N-acetylmuramic acid (MurNAc), or El-Ala and 1'-aminoferrocene-1-carboxylic acid (Fca). They were fully characterized by IR, H-1 NMR, C-13 NMR and CD spectroscopy as well as by FD mass spectrometry. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：678 / 684

页数：7

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