Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents

被引：39

作者：

Albaugh, Matthew D. ^{[1
]}

Orr, Catherine ^{[1
]}

Chaarani, Bader ^{[1
]}

Althoff, Robert R. ^{[1
]}

Allgaier, Nicholas ^{[1
]}

D'Alberto, Nicholas ^{[1
]}

Hudson, Kelsey ^{[1
]}

Mackey, Scott ^{[1
]}

Spechler, Philip A.

Banaschewski, Tobias ^{[2
]}

Bruehl, Ruediger ^{[4
]}

Bokde, Arun L. W. ^{[11
]}

Bromberg, Uli ^{[8
]}

Buechel, Christian ^{[8
]}

Cattrell, Anna ^{[13
]}

Conrod, Patricia J. ^{[14
,17
]}

Desrivieres, Sylvane ^{[13
]}

Flor, Herta ^{[3
]}

Frouin, Vincent ^{[21
]}

Gallinat, Juergen ^{[7
]}

Goodman, Robert ^{[15
]}

Gowland, Penny ^{[16
]}

Grimmer, Yvonne ^{[3
]}

Heinz, Andreas ^{[5
]}

Kappel, Viola ^{[6
]}

Martinot, Jean-Luc ^{[22
]}

Martinot, Marie-Laure Paillere ^{[23
,24
]}

Nees, Frauke ^{[3
]}

Orfanos, Dimitri Papadopoulos ^{[21
]}

Penttila, Jani ^{[25
]}

Poustka, Luise ^{[2
]}

Paus, Tomas ^{[18
,19
,20
]}

Smolka, Michael N. ^{[9
,10
]}

Struve, Maren ^{[3
]}

Walter, Henrik ^{[5
]}

Whelan, Robert ^{[12
]}

Schumann, Gunter ^{[13
]}

Garavan, Hugh ^{[1
]}

Potter, Alexandra S. ^{[1
]}

机构：

[1] Univ Vermont, Coll Med, Dept Psychiat, Univ Hlth Ctr Campus,1 South Prospect St, Burlington, VT 05401 USA

[2] Heidelberg Univ, Med Fac Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany

[3] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, Mannheim, Germany

[4] Phys Tech Bundesanstalt, Berlin, Germany

[5] Charite, Dept Psychiat & Psychotherapy, Berlin, Germany

[6] Charite, Dept Child & Adolescent Psychiat Psychosomat & Ps, Berlin, Germany

[7] Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, Germany

[8] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

[9] Tech Univ Dresden, Dept Psychiat, Dresden, Germany

[10] Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

[11] Trinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin, Ireland

[12] Univ Coll Dublin, Dept Psychol, Dublin, Ireland

[13] Kings Coll London, Med Res Council Social Genet & Dev Psychiat Ctr, London, England

[14] Kings Coll London, Dept Psychol Med & Psychiat, London, England

[15] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[16] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Nottingham, England

[17] Univ Montreal, Dept Psychiat, Ctr Hosp Univ St Justine Hosp, Montreal, PQ, Canada

[18] Baycrest, Rotman Res Inst, Toronto, ON, Canada

[19] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[20] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[21] CEA, Saclay Ctr, Neurospin, Paris, France

[22] Univ Paris 05, Univ Paris Sud, Sorbonne Paris Cite, INSERM,Unit Neuroimaging & Psychiat 1000, Paris, France

[23] Univ Paris Saclay, Univ Paris Sud, Serv Hosp Frederic Joliot, INSERM,Unit Neuroimaging & Psychiat 1000, Orsay, France

[24] Cochin Hosp, Maison Solenn, Dept Adolescent Psychopathol & Med, Paris, France

[25] Univ Tampere, Sch Med, Tampere, Finland

来源：

BIOLOGICAL PSYCHIATRY | 2017年 / 82卷 / 09期

基金：

美国国家卫生研究院; 英国惠康基金; 英国医学研究理事会;

关键词：

Attention-deficit/hyperactivity disorder; Inattention; Multi-informant; Neuroimaging; Reaction time variability; Ventromedial prefrontal cortex; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; GREY-MATTER REDUCTIONS; CORTICAL THICKNESS; FUNCTIONAL-ANATOMY; STRUCTURAL MRI; BASAL GANGLIA; FOLLOW-UP; ADULTS; ADHD; METAANALYSIS;

D O I：

10.1016/j.biopsych.2017.01.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BACKGROUND: Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability-an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression. METHODS: Psychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptoms were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole-brain voxelwise regressions with gray matter volume were calculated. RESULTS: Parent ratings of ADHD symptoms (Development and Well-Being Assessment and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with gray matter volume in an overlapping region of the ventromedial prefrontal cortex. Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology. CONCLUSIONS: This is the first study to reveal relationships between ventromedial prefrontal cortex structure and multi-informant measures of ADHD symptoms in a large population-based sample of adolescents. Our results indicate that ventromedial prefrontal cortex structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD.

引用

页码：660 / 668

页数：9

共 49 条

[1] Cerebellar Gray Matter Density in Females With ADHD Combined Type: A Cross-Sectional Voxel-Based Morphometry Study [J].