Synthesis and Biological Activities of Novel Pyrazole Oximes Containing Substituted Oxadiazole Moiety

In order to find novel pyrazole oximes with good bioactivities, a series of novel pyrazole oxime derivatives containing substituted oxadiazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were confirmed by H-1 NMR, C-13 NMR and elemental analysis. Preliminary bioassay data indicated that some title compounds showed good insecticidal activities. At the concentration of 500 mu g/mL, 9 compounds possessed insecticidal activity against Oriental army worm with 80%similar to 100%. When the concentration was lowered to 100 mu g/mL, 3 compounds still displayed significant insecticidal activity against Oriental army worm with 70%, 60% and 70%. Additionally, one compound had 60% insecticidal activity against Aphis medicaginis at 500 mu g/mL.