Chemoinformatic analysis of alkaloids isolated from Peganum genus

被引：2

作者：

Bayazeid, Omer ^{[1
]}

Nasibova, Tohfa ^{[2
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey

[2] Azerbaijan Med Univ, Dept Gen & Toxicol Chem, A Gasimzade 14, AZ-1022 Baku, Azerbaijan

来源：

MOLECULAR DIVERSITY | 2022年 / 26卷 / 04期

关键词：

Peganum; Alkaloids; Neuroactivity; Phytochemistry; Traditional usage; ACETYLCHOLINESTERASE INHIBITORS; HARMALA L; EXTRACT; SEEDS; QUINOLINE; PLANTS; PART;

D O I：

10.1007/s11030-021-10331-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peganum genus is rich with its high phytochemical and botanical variability. Peganum species have been used as a sedative, antitumor, analgesic and antidepressant. This paper aims to study the molecular diversity of Peganum genus and to shed more light on the structure-activity relationship of the alkaloids isolated from Peganum genus. All Peganum alkaloids were grouped according to their structural properties. A chemoinformatic approach (SwissTargetPrediction) was used to determine the molecular targets of these alkaloids. To analyze and visualize the results, R software was used to generate hierarchical clustering heatmaps. The results of this study can help researchers to better understand the structure-activity relationship of Peganum alkaloids and how substitution can affect the biological activity of those alkaloids. [GRAPHICS] .

引用

页码：2257 / 2267

页数：11

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