DNA Damage Response in Glioblastoma Mechanism for Treatment Resistance and Emerging Therapeutic Strategies

被引：9

作者：

Bonm, Alipi ^{[1
]}

Kesari, Santosh ^{[2
,3
]}

机构：

[1] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[2] Pacific Neurosci Inst, Santa Monica, CA USA

[3] St Johns Canc Inst, Santa Monica, CA USA

来源：

CANCER JOURNAL | 2021年 / 27卷 / 05期

关键词：

DNA damage response; double-strand break; glioblastoma; PARP; single-strand break; GROWTH-FACTOR RECEPTOR; IONIZING-RADIATION; HOMOLOGOUS RECOMBINATION; TUMOR-CELLS; PHASE-III; KINASE; INHIBITOR; REPAIR; TEMOZOLOMIDE; EXPRESSION;

D O I：

10.1097/PPO.0000000000000540

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma (GBM) is an intrinsically treatment-resistant tumor and has been shown to upregulate DNA damage response (DDR) components after treatment. DNA damage response signaling mediates treatment resistance by promoting cell cycle arrest in order to allow for DNA damage repair and avoid mitotic catastrophe. Therefore, targeting the DDR pathway is an attractive strategy to combat treatment resistance in GBM. In this review, we discuss the different DDR pathways and then summarize the current preclinical evidence for DDR inhibitors in GBM, as well as completed and ongoing clinical trials.

引用

收藏

页码：379 / 385

页数：7

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