Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma

被引：45
作者：
Leppaenen, Joni [1 ,2 ]
Lindholm, Ville [1 ,2 ]
Isohookana, Joel [1 ,2 ]
Haapasaari, Kirsi-Maria [1 ,2 ]
Karihtala, Peeter [1 ,2 ]
Lehenkari, Petri P. [1 ,2 ]
Saarnio, Juha [1 ,2 ]
Kauppila, Joonas H. [1 ,2 ,3 ,4 ]
Karttunen, Tuomo J. [1 ,2 ]
Helminen, Olli [1 ,2 ]
Huhta, Heikki [1 ,2 ]
机构：
[1] Univ Oulu, Med Res Ctr Oulu, Canc & Translat Med Res Unit, Oulu, Finland
[2] Oulu Univ Hosp, Oulu, Finland
[3] Karolinska Inst, Dept Mol Med & Surg, Upper Gastrointestinal Surg, Stockholm, Sweden
[4] Karolinska Univ Hosp, Stockholm, Sweden
来源：
PANCREAS | 2019年 / 48卷 / 01期
关键词：
extracellular matrix; fibronectin; pancreatic cancer; tenascin C; tumor-stroma ratio; INDEPENDENT PREDICTOR; PROGNOSTIC-FACTOR; BREAST-CANCER; SURVIVAL; MICROENVIRONMENT; EXPRESSION; PROGRESSION; CARCINOMA; ESOPHAGUS;
D O I：
10.1097/MPA.0000000000001195
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Objectives: Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role and tumor-stroma ratio in PDAC are not well known. The aim of this study was to evaluate tenascin C and fibronectin expression and tumor-stroma ratio and their prognostic relevance in PDAC. Methods: Ninety-five resected PDACs were immunohistochemically stained for tenascin C and fibronectin, and the expression was separately assessed in tumor bulk and front. Tumor-stroma ratio was determined with sections stained with hematoxylin-eosin. Results: Tenascin C and fibronectin were abundantly expressed in the stroma of PDAC, but absent in adjacent normal pancreatic tissue. Fibronectin expression of the bulk was associated with high T class (P = 0.045). In the main analysis, tenascin C and fibronectin expression and tumor-stroma ratio were not associated with patient survival. In a subgroup analysis of early-stage PDAC (T1-T2 tumors), high tenascin C expression in the tumor bulk was associated with poor prognosis (hazard ratio, 8.23; 95% confidence interval, 2.71-24.96). Conclusions: Tenascin C and fibronectin are abundantly expressed in PDAC, but they seem to have no major association with patient survival. However, in early-stage PDAC, tenascin C expression of the tumor bulk may have prognostic impact. Tumor-stroma ratio has no prognostic value in PDAC.
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页码：43 / 48
页数：6
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