Fatigue in Multiple Sclerosis Is Associated with Reduced Expression of Interleukin-10 and Worse Prospective Disease Activity

被引：13

作者：

Gilio, Luana ^{[1
]}

Buttari, Fabio ^{[1
]}

Pavone, Luigi ^{[1
]}

Iezzi, Ennio ^{[1
]}

Galifi, Giovanni ^{[1
]}

Dolcetti, Ettore ^{[1
]}

Azzolini, Federica ^{[1
]}

Bruno, Antonio ^{[1
]}

Borrelli, Angela ^{[1
]}

Storto, Marianna ^{[1
]}

Furlan, Roberto ^{[2
]}

Finardi, Annamaria ^{[2
]}

Pekmezovic, Tatjana ^{[3
,4
]}

Drulovic, Jelena ^{[3
,5
]}

Mandolesi, Georgia ^{[6
,7
]}

Fresegna, Diego ^{[6
]}

Vanni, Valentina ^{[6
]}

Centonze, Diego ^{[1
,8
]}

Bassi, Mario Stampanoni ^{[1
]}

机构：

[1] IRCCS Neuromed, I-86077 Pozzilli, Italy

[2] Ist Sci San Raffaele, Inst Expt Neurol INSpe, Div Neurosci, Clin Neuroimmunol Unit, I-20132 Milan, Italy

[3] Univ Belgrade, Fac Med, Belgrade 11000, Serbia

[4] Univ Belgrade, Fac Med, Inst Epidemiol, Belgrade 11000, Serbia

[5] Clin Ctr Serbia, Clin Neurol, Belgrade 11000, Serbia

[6] IRCCS San Raffaele Roma, Synapt Immunopathol Lab, I-00163 Rome, Italy

[7] Univ Rome San Raffaele, Dept Human Sci & Qual Life Promot, I-00166 Rome, Italy

[8] Tor Vergata Univ, Dept Syst Med, I-00133 Rome, Italy

来源：

BIOMEDICINES | 2022年 / 10卷 / 09期

关键词：

relapsing-remitting multiple sclerosis (RR-MS); fatigue; inflammation; IL-10; NEDA-3; T2 lesion load; MESSENGER-RNA; LESION LOAD; INFLAMMATION; IMPAIRMENT; DISABILITY; DIAGNOSIS; SCALE; PAIN;

D O I：

10.3390/biomedicines10092058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In multiple sclerosis (MS), fatigue is a frequent symptom that negatively affects quality of life. The pathogenesis of fatigue is multifactorial and inflammation may play a specific role. To explore the association between fatigue, central inflammation and disease course in MS in 106 relapsing-remitting (RR)-MS patients, clinical characteristics, including fatigue and mood, were explored at the time of diagnosis. NEDA (no evidence of disease activity)-3 status after one-year follow up was calculated. Cerebrospinal fluid (CSF) levels of a set of proinflammatory and anti-inflammatory molecules and peripheral blood markers of inflammation were also analyzed. MRI structural measures were explored in 35 patients. A significant negative correlation was found at diagnosis between fatigue measured with the Modified Fatigue Impact Scale (MFIS) and the CSF levels of interleukin (IL)-10. Conversely, no significant associations were found with peripheral markers of inflammation. Higher MFIS scores were associated with reduced probability to reach NEDA-3 status after 1-year follow up. Finally, T2 lesion load showed a positive correlation with MFIS scores and a negative correlation with CSF IL-10 levels at diagnosis. CSF inflammation, and particularly the reduced expression of the anti-inflammatory molecule IL-10, may exacerbate fatigue. Fatigue in MS may reflect subclinical CSF inflammation, predisposing to greater disease activity.

引用

页数：13

共 46 条

[1] Fatigue in Multiple Sclerosis: Is it related to cytokines and hypothalamic-pituitary-adrenal axis? [J].