Copper-Catalyzed Cross Dehydrogenative Coupling Reactions of Tertiary Amines with Ketones or Indoles

被引：128

作者：

Yang, Fei ^{[1
]}

Li, Jian ^{[1
]}

Xie, Jin ^{[1
]}

Huang, Zhi-Zhen ^{[1
,2
]}

机构：

[1] Nanjing Univ, Coll Chem & Chem Engn, Key Lab Mesoscop Chem MOE, Nanjing 210093, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 22期

基金：

中国国家自然科学基金;

关键词：

SP(3) C-H; OXIDATIVE CYANATION; HYDROGEN-PEROXIDE; BOND; ACTIVATION; ALKALOIDS;

D O I：

10.1021/ol102252n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel cross dehydrogenative coupling (CDC) reaction of N,N-dimethylanilines with methyl ketones by cooperative copper and aminocatalysis has been developed, which leads to the formation of beta-arylamino ketones in 42-73% yields. Moreover, the copper-catalyzed alkylation of free (NH) indoles with N,N-dimethylanilines via CDC reaction is also presented, affording alkylated indoles in 52-78% yields.

引用

页码：5214 / 5217

页数：4

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