Immunosuppressive effect of bactobolamine on canine renal allotransplantation

In this study, we evaluated the immunosuppressive effect of bactobolamine (BBL) on canine renal allografts. In BBL group (n = 8), recipient dogs were treated with BBL monotherapy from the first postoperative day (POD) for more than 14 days. BBL were administered by continuous intravenous infusion at a daily dose of 100 mg/kg, using drug infusion balloon catheter. In the control group (n = 10), recipients were not given any immunosuppressive drugs after the operation. The mean survival time of BBL group (24.6 +/- 5.6 days) was significantly prolonged, when compared with the control group (17.4 +/- 4.2 days). The mean serum creatinine level on 14th postoperative day in the BBL group (1.0 +/- 0.3 mg/dl) was significantly lower than that in the control group (8.1 +/- 3.7 mg/dl). Although severe toxicities such as anorexia, diarrhea, vomiting, body weight loss and pulmonary congestion or edema were frequently observed in BBL group, acute rejection was almost completely prevented in BBL group.