CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

被引：8

作者：

Garcia-Labastida, Laura ^{[1
]}

Garza-Guajardo, Raquel ^{[1
]}

Barboza-Quintana, Oralia ^{[1
]}

Pablo Rodriguez-Sanchez, Iram ^{[2
]}

Ancer-Rodriguez, Jesus ^{[1
]}

Pablo Flores-Gutierrez, Juan ^{[1
]}

Sofa Gomez-Macias, Gabriela ^{[1
]}

机构：

[1] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Dept Anat Patol & Citopatol, Monterrey 64460, Nuevo Leon, Mexico

[2] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Dept Genet, Monterrey 64460, Nuevo Leon, Mexico

来源：

BIOLOGICAL RESEARCH | 2014年 / 47卷

关键词：

Breast mucinous carcinoma; Inmunohistochemical; Intestinal differentiation; INVASIVE DUCTAL CARCINOMAS; NO SPECIAL TYPE; BETA-CATENIN; NEUROENDOCRINE DIFFERENTIATION; PROGNOSTIC-SIGNIFICANCE; COLLOID CARCINOMA; EXPRESSION; MUC5AC; PANCREAS; DISTINCT;

D O I：

10.1186/0717-6287-47-43

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. Results: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. Conclusions: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.

引用

页数：5

共 36 条

[1] Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs - Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas [J].