Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α-hydroxyphosphonate Derivatives

被引：17

作者：

Aouani, Iyadh ^{[1
]}

Lahbib, Karima ^{[1
]}

Touil, Soufiane ^{[1
]}

机构：

[1] Univ Carthage, Fac Sci Bizerta, Dept Chem, Lab Heteroatom Organ Chem, Jarzouna 7021, Tunisia

来源：

MEDICINAL CHEMISTRY | 2015年 / 11卷 / 02期

关键词：

alpha-Hydroxyphosphonates; gamma-cyano-alpha-hydroxyphosphonates; gamma-ketonitriles; green synthesis; antioxidant activity; CONVENIENT; INHIBITORS; PHOSPHONATE; ALDEHYDES; ANALOGS; KETONES; STRESS; CANCER; ASSAY;

D O I：

10.2174/1573406410666140706154046

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herein we report an efficient, simple and green synthesis of novel types of alpha-hydroxyphosphonates bearing a nitrile group, from the reaction of gamma-ketonitriles with dialkyl phosphites in the presence of magnesium oxide as solid support, under solvent-free conditions. All the title compounds were screened for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical, reducing power and ferrous ion chelating (FIC) methods and they showed significant antioxidant activity.

引用

页码：206 / 213

页数：8

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