Ambient mass spectrometry in metabolomics

被引:58
作者
Clendinen, Chaevien S. [1 ,2 ]
Eugenia Monge, Maria [3 ]
Fernandez, Facundo M. [1 ,2 ]
机构
[1] Georgia Inst Technol, Sch Chem & Biochem, 901 Atlantic Dr NW, Atlanta, GA 30332 USA
[2] Georgia Inst Technol, Petit Inst Bioengn & Biosci IBB, Atlanta, GA 30332 USA
[3] Consejo Nacl Invest Cient & Tecn, Ctr Invest Bionanociencias CIBION, Godoy Cruz 2390,C1425FQD, Buenos Aires, Argentina
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
DESORPTION ELECTROSPRAY-IONIZATION; SONIC-SPRAY IONIZATION; NUCLEAR-MAGNETIC-RESONANCE; PARTIAL LEAST-SQUARES; MODE DIRECT ANALYSIS; REAL-TIME; ATMOSPHERIC-PRESSURE; IN-SITU; PLANT METABOLOMICS; INFRARED-LASER;
D O I
10.1039/c7an00700k
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Since the introduction of desorption electrospray ionization (DESI) mass spectrometry (MS), ambient MS methods have seen increased use in a variety of fields from health to food science. Increasing its popularity in metabolomics, ambient MS offers limited sample preparation, rapid and direct analysis of liquids, solids, and gases, in situ and in vivo analysis, and imaging. The metabolome consists of a constantly changing collection of small (<1.5 kDa) molecules. These include endogenous molecules that are part of primary metabolism pathways, secondary metabolites with specific functions such as signaling, chemicals incorporated in the diet or resulting from environmental exposures, and metabolites associated with the microbiome. Characterization of the responsive changes of this molecule cohort is the principal goal of any metabolomics study. With adjustments to experimental parameters, metabolites with a range of chemical and physical properties can be selectively desorbed and ionized and subsequently analyzed with increased speed and sensitivity. This review covers the broad applications of a variety of ambient MS techniques in four primary fields in which metabolomics is commonly employed.
引用
收藏
页码:3101 / 3117
页数:17
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