Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension

被引:19
作者
Issa, Naim [1 ,3 ]
Sanchez, Otto A. [1 ]
Kukla, Aleksandra [1 ,3 ]
Riad, Samy M. [1 ]
Berglund, Danielle M. [2 ]
Ibrahim, Hassan N. [1 ,4 ]
Matas, Arthur J. [2 ]
机构
[1] Univ Minnesota, Dept Med, Div Renal Dis & Hypertens, Box 736 UMHC, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Surg, Div Transplant Surg, Box 242 UMHC, Minneapolis, MN 55455 USA
[3] Mayo Clin, 200 First St SW, Rochester, MN 55905 USA
[4] Houston Methodist, Houston, TX USA
关键词
body mass index; diabetes mellitus; hypertension; Living kidney donation; long-term risk; obesity; STAGE RENAL-DISEASE; CONCORDANCE; OBESITY; DONORS; MASS;
D O I
10.1111/ctr.13360
中图分类号
R61 [外科手术学];
学科分类号
摘要
In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of postdonation weight gain trends and any associated risks. We tracked serial BMIs in 940 donors for a median (IQ range) follow-up of 22.3 (15.4-35.8) years. We studied the impact of postdonation weight gain in a model adjusted for family history of HTN or DM. Donor characteristics included age, sex, smoking, fasting blood glucose, eGFR, systolic and diastolic BP, and BMI at time of donation and time postdonation. Postdonation weight gain was associated with a significant increase in the relative risk of developing HTN RR 1.93 (95% CI 1.51-2.46) (P < 0.001) and/or DM RR 4.18 (95% CI 2.05-8.5) (P < 0.0001), but not (to date) cardiovascular disease (CVD), reduced eGFR or death. Like the general population, donors gained weight as they aged; a higher BMI was associated with higher incidence of DM and HTN. Postdonation care should include ongoing counseling on the risks of substantial weight gain.
引用
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页数:8
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共 19 条
  • [1] Patterns of End-Stage Renal Disease Caused by Diabetes, Hypertension, and Glomerulonephritis in Live Kidney Donors
    Anjum, S.
    Muzaale, A. D.
    Massie, A. B.
    Bae, S.
    Luo, X.
    Grams, M. E.
    Lentine, K. L.
    Garg, A. X.
    Segev, D. L.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (12) : 3540 - 3547
  • [2] Obesity
    Haslam, DW
    James, WPT
    [J]. LANCET, 2005, 366 (9492) : 1197 - 1209
  • [3] Body mass index and risk for end-stage renal disease
    Hsu, CY
    McCulloch, CE
    Iribarren, C
    Darbinian, J
    Go, AS
    [J]. ANNALS OF INTERNAL MEDICINE, 2006, 144 (01) : 21 - 28
  • [4] Renal Function Profile in White Kidney Donors: The First 4 Decades
    Ibrahim, Hassan N.
    Foley, Robert N.
    Reule, Scott A.
    Spong, Richard
    Kukla, Aleksandra
    Issa, Naim
    Berglund, Danielle M.
    Sieger, Gretchen K.
    Matas, Arthur J.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (09): : 2885 - 2893
  • [5] Long-Term Consequences of Kidney Donation.
    Ibrahim, Hassan N.
    Foley, Robert
    Tan, LiPing
    Rogers, Tyson
    Bailey, Robert F.
    Guo, Hongfei
    Gross, Cynthia R.
    Matas, Arthur J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (05) : 459 - 469
  • [6] LONG-TERM EFFECTS OF REDUCED RENAL MASS IN HUMANS
    KASISKE, BL
    MA, JZ
    LOUIS, TA
    SWAN, SK
    [J]. KIDNEY INTERNATIONAL, 1995, 48 (03) : 814 - 819
  • [7] Obesity and prevalent and incident CKD: The hypertension detection and follow-up program
    Kramer, H
    Luke, A
    Bidani, A
    Cao, GC
    Cooper, R
    McGee, D
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2005, 46 (04) : 587 - 594
  • [8] A New Equation to Estimate Glomerular Filtration Rate
    Levey, Andrew S.
    Stevens, Lesley A.
    Schmid, Christopher H.
    Zhang, Yaping
    Castro, Alejandro F., III
    Feldman, Harold I.
    Kusek, John W.
    Eggers, Paul
    Van Lente, Frederick
    Greene, Tom
    Coresh, Josef
    [J]. ANNALS OF INTERNAL MEDICINE, 2009, 150 (09) : 604 - 612
  • [9] Obesity increases the risk of end-stage renal disease among living kidney donors
    Locke, Jayme E.
    Reed, Rhiannon D.
    Massie, Allan
    MacLennan, Paul A.
    Sawinski, Deirdre
    Kumar, Vineeta
    Mehta, Shikha
    Mannon, Roslyn B.
    Gaston, Robert
    Lewis, Cora E.
    Segev, Dorry L.
    [J]. KIDNEY INTERNATIONAL, 2017, 91 (03) : 699 - 703
  • [10] Quantifying Postdonation Risk of ESRD in Living Kidney Donors
    Massie, Allan B.
    Muzaale, Abimereki D.
    Luo, Xun
    Chow, Eric K. H.
    Locke, Jayme E.
    Nguyen, Anh Q.
    Henderson, Macey L.
    Snyder, Jon J.
    Segev, Dorry L.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (09): : 2749 - 2755