Solid Solution Hardening of Molecular Crystals: Tautomeric Polymorphs of Omeprazole

被引：85

作者：

Mishra, Manish Kumar ^{[1
]}

Ramamurty, Upadrasta ^{[2
,3
]}

Desiraju, Gautam R. ^{[1
]}

机构：

[1] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Mat Engn, Bangalore 560012, Karnataka, India

[3] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21589, Saudi Arabia

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 05期

关键词：

MECHANICAL-PROPERTIES; ORGANIC-CRYSTALS; SINGLE-CRYSTAL; NANOINDENTATION; BEHAVIOR; COCRYSTALS; PRESSURE;

D O I：

10.1021/ja512817f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the context of processing of molecular solids, especially pharmaceuticals, hardness is an important property that often determines the manufacturing steps employed. Through nanoindentation studies on a series of omeprazole polymorphs, in which the proportions of the 5- and 6-methoxy tautomers vary systematically, we demonstrate that solid-solution strengthening can be effectively employed to engineer the hardness of organic solids. High hardness can be attained by increasing lattice resistance to shear sliding of molecular layers during plastic deformation.

引用

页码：1794 / 1797

页数：4

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