Transition metal-free tandem pyridinyl-allyl-allyl cross-coupling reaction

被引：4

作者：

Zhang, Lili ^{[1
]}

Chen, Zhengkai ^{[1
]}

Li, Hongli ^{[1
]}

Yin, Wenguang ^{[1
]}

Xu, Jianfeng ^{[1
]}

Miao, Maozhong ^{[1
]}

Ren, Hongjun ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 18期

关键词：

Allylation; cross-coupling; metal-free; pyridines; tandem reaction; C-H ALLYLATION; ARYL GRIGNARD-REAGENTS; DIARYLMETHANE PRONUCLEOPHILES; CONJUGATE ADDITION; ALKYLATION; HALIDES; BONDS; HETEROCYCLES; DERIVATIVES; ACTIVATION;

D O I：

10.1080/00397911.2017.1339803

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition metal-free, direct one-pot domino allylation reaction of 2-pyridinyl Grignard reagents with polysubstituted allyl chlorides for the regioselective synthesis of pyridinyl-substituted 1,5-diene derivatives has been disclosed. The reaction presumably proceeded through the coupling of polysubstituted allyl chloride to 2-PyMgX, which was in situ generated from 2-bromopyridine with i-PrMgClLiCl.

引用

页码：1668 / 1675

页数：8

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