mRNA quality control:: An ancient machinery recognizes and degrades mRNAs with nonsense codons

被引：174

作者：

Behm-Ansmant, Isabelle ^{[1
]}

Kashima, Isao ^{[1
]}

Rehwinkel, Jan ^{[1
]}

Sauliere, Jerome ^{[1
]}

Wittkopp, Nadine ^{[1
]}

Izaurralde, Elisa ^{[1
]}

机构：

[1] MPI Dev Biol, D-72076 Tubingen, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 15期

关键词：

EJC; mRNA decay; NMD; PABP;

D O I：

10.1016/j.febslet.2007.05.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway which ensures the rapid degradation of mRNAs containing premature translation termination codons (PTCs or nonsense codons), thereby preventing the accumulation of truncated and potentially harmful proteins. In this way, the NMD pathway contributes to suppressing or exacerbating the clinical manifestations of specific human genetic disorders. Studies in model organisms have led to the identification of the effectors of the NMD pathway, and illuminated the mechanisms by which premature stops are discriminated from natural stops, so that only the former trigger rapid mRNA degradation. These studies are providing important insights that will aid the development of new treatments for at least some human genetic diseases. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2845 / 2853

页数：9

共 59 条

[1] A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay [J].