Case Report: Omalizumab Successfully Treated Recalcitrant Bullous Pemphigoid in an Elderly Patient with Multiple Comorbidities

被引：2
作者：
Liu, Jue [1 ]
Xiang, Tingkai [2 ]
Wang, Wei [3 ]
Bu, Zhangyu [1 ,4 ]
机构：
[1] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Dermatol, Sch Med, Hangzhou, Peoples R China
[2] Zhejiang Chinese Med Univ, Sch Med 4, Hangzhou, Peoples R China
[3] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Pathol, Sch Med, Hangzhou, Peoples R China
[4] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Dermatol, Sch Med, 261 Huansha Rd, Hangzhou, Peoples R China
来源：
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2022年 / 15卷
关键词：
bullous pemphigoid; comorbidities; omalizumab; elderly; case report; IGE AUTOANTIBODIES; MORTALITY; BP180;
D O I：
10.2147/CCID.S373682
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Bullous pemphigoid (BP) is an autoimmune blistering disease mainly affecting elderly individuals. Comorbidities are common in patients with BP and have been found to complicate the management and prognosis. We describe a patient with multiple comorbidities who was successfully treated with omalizumab and suggest omalizumab as a good alternative therapy for BP to prevent treatment-related complications in elderly patients with a poor general condition.
引用
收藏
页码：1391 / 1396
页数：6
相关论文
共 21 条
[1]   Omalizumab for the Treatment of Bullous Pemphigoid: A Systematic Review of Efficacy and Safety [J].
D'Aguanno, Kathleen ;
Gabrielli, Sofianne ;
Ouchene, Lydia ;
Muntyanu, Anastasiya ;
Ben-Shoshan, Moshe ;
Zhang, Xun ;
Iannattone, Lisa ;
Netchiporouk, Elena .
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2022, 26 (04) :404-413
[2]   The clinical response to omalizumab in chronic spontaneous urticaria patients is linked to and predicted by IgE levels and their change [J].
Ertas, R. ;
Ozyurt, K. ;
Atasoy, M. ;
Hawro, T. ;
Maurer, M. .
ALLERGY, 2018, 73 (03) :705-712
[3]   Bullous pemphigoid successfully treated with omalizumab [J].
Gonul, Muzeyyen ;
Keseroglu, Havva Ozge ;
Ergin, Can ;
Ozcan, Ibrahim ;
Erdem, Ozlem .
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 2016, 82 (05) :577-+
[4]   Detection of IgE autoantibodies to BP180 and BP230 and their relationship to clinical features in bullous pemphigoid [J].
Hashimoto, T. ;
Ohzono, A. ;
Teye, K. ;
Numata, S. ;
Hiroyasu, S. ;
Tsuruta, D. ;
Hachiya, T. ;
Kuroda, K. ;
Hashiguchi, M. ;
Kawakami, T. ;
Ishii, N. .
BRITISH JOURNAL OF DERMATOLOGY, 2017, 177 (01) :141-151
[5]   Effects of Omalizumab on FcεRI and IgE Expression in Lesional Skin of Bullous Pemphigoid [J].
Jafari, S. Morteza Seyed ;
Gadaldi, Karolina ;
Feldmeyer, Laurence ;
Yawalkar, Nikhil ;
Borradori, Luca ;
Schlapbach, Christoph .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[6]   A Retrospective Consecutive Case-series Study on the Effect of Systemic Treatment, Length of Admission Time, and Co-morbidities in 98 Bullous Pemphigoid Patients Admitted to a Tertiary Centre [J].
Kibsgaard, Line ;
Bay, Bjorn ;
Deleuran, Mette ;
Vestergaard, Christian .
ACTA DERMATO-VENEREOLOGICA, 2015, 95 (03) :307-311
[7]   Rituximab and Omalizumab for the Treatment of Bullous Pemphigoid: A Systematic Review of the Literature [J].
Kremer, Noa ;
Snast, Igor ;
Cohen, Efrat Solomon ;
Hodak, Emmilia ;
Mimouni, Daniel ;
Lapidoth, Moshe ;
Mazor, Sigal ;
Levi, Assi .
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2019, 20 (02) :209-216
[8]   Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation [J].
Kridin, K. .
BRITISH JOURNAL OF DERMATOLOGY, 2018, 179 (05) :1141-1147
[9]   Mortality of patients with bullous pemphigoid in Korea [J].
Lee, Ji Hye ;
Kim, Soo-Chan .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 71 (04) :676-683
[10]   Association of bullous pemphigoid and comorbid health conditions: a case-control study [J].
Lee, Sherry ;
Rastogi, Supriya ;
Hsu, Derek Y. ;
Nardone, Beatrice ;
Silverberg, Jonathan I. .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 2021, 313 (05) :327-332
123