What are the later life contributions to reserve, resilience, and compensation?

被引：18
作者：
Burke, Sara N. [1 ,2 ]
Mormino, Elizabeth C. [3 ]
Rogalski, Emily J. [4 ]
Kawas, Claudia H. [5 ,6 ]
Willis, Robert J. [7 ,8 ]
Park, Denise C. [9 ]
机构：
[1] Univ Florida, McKnight Brain Inst, Gainesville, FL USA
[2] Univ Florida, Dept Neurosci, Gainesville, FL 32610 USA
[3] Stanford Sch Med, Dept Neurol & Neurosci, Stanford, CA 94305 USA
[4] Northwestern Univ, Dept Psychiat & Behav Sci, Feinberg Sch Med, Mesulam Ctr Cognit Neurol & Alzheimers Dis, Chicago, IL 60611 USA
[5] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA
[6] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA
[7] Univ Michigan, Dept Econ, Ann Arbor, MI 48109 USA
[8] Univ Michigan, Inst Social Res, Ann Arbor, MI USA
[9] Univ Texas Dallas, Sch Behav & Brain Sci, Ctr Vital Longev, Dallas, TX 75080 USA
来源：
NEUROBIOLOGY OF AGING | 2019年 / 83卷
基金：
美国国家卫生研究院;
关键词：
Resilience; Cognitive decline; Plasticity; Compensation; Maintenance; OLDEST-OLD; DEMENTIA; MEMORY; ALZHEIMERS; SUPERIOR;
D O I：
10.1016/j.neurobiolaging.2019.03.023
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Many studies have shown that early-life experiences can contribute to later life cognitive reserve and resilience. However, there is evidence to suggest that later life experiences and lifestyle choices can also play a vital role in the brain's ability to respond to and compensate for neural insults associated with aging. Engaging in a diversity of behaviorally, socially, and cognitively rich activities may forge new neural pathways that can perhaps provide greater flexibility in confronting the challenges associated with accumulating brain pathology. Studies of cognitively normal individuals with pathology and of individuals who have aged exceptionally well may provide insights that are generalizable to the overall elderly population. (C) 2019 The Authors. Published by Elsevier Inc.
引用
收藏
页码：140 / 144
页数：5
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